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Muropeptide Modification-Amidation of Peptidoglycan D-Glutamate Does Not Affect the Proinflammatory Activity of Staphylococcus aureus

Cellular and Molecular Microbiology Division, Medical Microbiology and Hygiene Institute, University of Tübingen, Tübingen, Germany,¹ Medical and Natural Sciences Research Center, University of Tübingen, Tübingen, Germany,² Microbial Genetics, University of Tübingen, Tübingen, Germany,³ Medical Microbiology Institute, University of Zürich, Zürich, Switzerland⁴

Received 29 September 2006/ Returned for modification 30 November 2006/ Accepted 18 January 2007

Peptidoglycan muropeptides, potent proinflammatory components, are amidated in Staphylococcus aureus for unknown reasons. To study whether this modification may modulate proinflammatory capacity, cytokine induction by isogenic S. aureus strains with different amidation levels and by synthetic amidated/nonamidated muramyldipeptides was evaluated. However, amidation did not significantly affect cytokine induction. This finding contributes to defining peptidoglycan receptor specificities and indicates that further rationales for muropeptide amidation have to be considered.

Published ahead of print on 29 January 2007.

Editor: J. N. Weiser