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Infection and Immunity, May 2007, p. 2621-2625, Vol. 75, No. 5
0019-9567/07/$08.00+0     doi:10.1128/IAI.00918-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

In Vivo Adaptation of the Wayne Model of Latent Tuberculosis{triangledown}

Lisa Woolhiser, Marcela Henao Tamayo, Baolin Wang, Veronica Gruppo, John T. Belisle, Anne J. Lenaerts, Randall J. Basaraba, and Ian M. Orme*

Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado 80523

Received 8 June 2006/ Returned for modification 21 September 2006/ Accepted 25 January 2007

Cultures of Mycobacterium tuberculosis grown under oxygen depletion conditions enter into a state of nonreplicating persistence that may reflect a physiologically latent state. When these cultures were harvested and injected intranasally into mice, no bacteria could be recovered from the lungs for about 3 weeks, but after that evidence of regrowth was observed. Preimmunization of mice with a panel of selected vaccine candidates slowed or prevented this event. This simple model has potential for identifying vaccines targeting latent tuberculosis.

* Corresponding author. Mailing address: Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523. Phone: (970) 491-5777. Fax: (970) 491-5125. E-mail: Ian.Orme{at}ColoState.edu

{triangledown} Published ahead of print on 5 February 2007.

Editor: J. L. Flynn

Infection and Immunity, May 2007, p. 2621-2625, Vol. 75, No. 5
0019-9567/07/$08.00+0     doi:10.1128/IAI.00918-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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Copyright © 2007 by the American Society for Microbiology. All rights reserved.