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Infection and Immunity, May 2007, p. 2634-2637, Vol. 75, No. 5
0019-9567/07/$08.00+0     doi:10.1128/IAI.01372-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Enterococcus faecalis Mutations Affecting Virulence in the Caenorhabditis elegans Model Host{triangledown}

Arash Maadani,1 Kristina A. Fox,1 Elftherios Mylonakis,2 and Danielle A. Garsin1*

Department of Microbiology and Molecular Genetics, The University of Texas Health Science Center at Houston, Houston, Texas,1 Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts2

Received 25 August 2006/ Returned for modification 21 September 2006/ Accepted 7 February 2007

Enterococcus faecalis transposon insertion mutants were screened for attenuated killing of the nematode model host Caenorhabditis elegans. The genes disrupted in the attenuated mutants encode a variety of factors including transcriptional regulators, transporters, and damage control and repair systems. Five of nine mutants tested were attenuated in a mouse peritonitis model.

* Corresponding author. Mailing address: Department of Microbiology and Molecular Genetics, The University of Texas Health Science Center at Houston, 6431 Fannin St./MSB 1.174, Houston, TX 77030. Phone: (713) 500-5454. Fax: (713) 500-5499. E-mail: Danielle.A.Garsin{at}uth.tmc.edu

{triangledown} Published ahead of print on 16 February 2007.

Editor: A. Camilli

Infection and Immunity, May 2007, p. 2634-2637, Vol. 75, No. 5
0019-9567/07/$08.00+0     doi:10.1128/IAI.01372-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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