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Infection and Immunity, May 2007, p. 2638-2641, Vol. 75, No. 5
0019-9567/07/$08.00+0     doi:10.1128/IAI.01320-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Enhancement of Macrophage Stimulation by Lipoteichoic Acid and the Costimulant Hemoglobin Is Dependent on Toll-Like Receptors 2 and 4{triangledown}

Kathleen H. Cox,1 Itzhak Ofek,2 and David L. Hasty1,3*

Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, 800 Madison Avenue, Memphis, Tennessee 38163,1 Department of Human Microbiology, Tel Aviv University, Tel Aviv 69978, Israel,2 Research Service (151), Department of Veterans Affairs Medical Center, 1030 Jefferson Avenue, Memphis, Tennessee 381043

Received 16 August 2006/ Returned for modification 14 November 2006/ Accepted 2 February 2007

Macrophage stimulation by lipoteichoic acid (LTA) and hemoglobin (Hb) requires Toll-like receptors 2 and 4 (TLR2 and -4). There are two distinct temporal phases of interleukin-6 (IL-6) production. The first results in a slight enhancement of IL-6 secretion in response to LTA plus Hb compared to that with LTA alone and is TLR4 independent. The second requires TLR4 and accounts for most of the additional stimulation seen with LTA plus Hb.

* Corresponding author. Mailing address: Research Service (151), Department of Veterans Affairs Medical Center, 1030 Jefferson Avenue, Memphis, TN 38104. Phone: (901) 523-8990. Fax: (901) 577-7273. E-mail: dhasty{at}utmem.edu

{triangledown} Published ahead of print on 12 February 2007.

Editor: V. J. DiRita

Infection and Immunity, May 2007, p. 2638-2641, Vol. 75, No. 5
0019-9567/07/$08.00+0     doi:10.1128/IAI.01320-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Tanabe, S.-i., Gottschalk, M., Grenier, D. (2008). Hemoglobin and Streptococcus suis cell wall act in synergy to potentiate the inflammatory response of monocyte-derived macrophages. Innate Immunity 14: 357-363 [Abstract]  
  • Meron-Sudai, S., Matityahou, A., Keisari, Y., Cox, K. H., Hasty, D. L., Ofek, I. (2008). Lipoteichoic Acid Synergizes with Glycosphingolipids To Potently Stimulate Secretion of Interleukin-6 from Human Blood Cells. CVI 15: 1309-1315 [Abstract] [Full Text]  
  • Knapp, S., von Aulock, S., Leendertse, M., Haslinger, I., Draing, C., Golenbock, D. T., van der Poll, T. (2008). Lipoteichoic Acid-Induced Lung Inflammation Depends on TLR2 and the Concerted Action of TLR4 and the Platelet-Activating Factor Receptor. J. Immunol. 180: 3478-3484 [Abstract] [Full Text]  


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