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Infection and Immunity, May 2007, p. 2642-2644, Vol. 75, No. 5
0019-9567/07/$08.00+0     doi:10.1128/IAI.01622-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

A Booster Vaccination with Mycobacterium bovis BCG Does Not Increase the Protective Effect of the Vaccine against Experimental Mycobacterium ulcerans Infection in Mice{triangledown}

Audrey Tanghe, Pierre-Yves Adnet, Tatiana Gartner, and Kris Huygen*

Mycobacterial Immunology, WIV-Pasteur Institute Brussels, 642 Engelandstraat, B-1180 Brussels, Belgium

Received 7 October 2006/ Returned for modification 18 December 2006/ Accepted 12 February 2007

Buruli ulcer, caused by Mycobacterium ulcerans, is a necrotizing skin disease emerging particularly in West Africa. M. bovis BCG vaccine offers only short-term protection against experimental footpad infection of C57BL/6 mice with M. ulcerans, and the duration of this protection cannot be prolonged by a booster vaccination.

* Corresponding author. Mailing address: WIV-Pasteur Institute Brussels, Mycobacterial Immunology, 642 Engelandstraat, B-1180 Brussels, Belgium. Phone: 32 2 373 33 70. Fax: 32 2 373 33 67. E-mail: khuygen{at}pasteur.be

{triangledown} Published ahead of print on 26 February 2007.

Editor: J. L. Flynn

Infection and Immunity, May 2007, p. 2642-2644, Vol. 75, No. 5
0019-9567/07/$08.00+0     doi:10.1128/IAI.01622-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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