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 Previous Article

Infection and Immunity, May 2007, p. 2645-2647, Vol. 75, No. 5
0019-9567/07/$08.00+0     doi:10.1128/IAI.01317-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

The Genome of Non-O1 Vibrio cholerae NRT36S Demonstrates the Presence of Pathogenic Mechanisms That Are Distinct from Those of O1 Vibrio cholerae{triangledown}

Yuansha Chen,1 Judith A. Johnson,1,2 Gordon D. Pusch,3 J. Glenn Morris Jr.,1 and O. Colin Stine1*

University of Maryland, Baltimore, Maryland 21201,1 Veterans Affairs Maryland Health Care System, Baltimore, Maryland 21201,2 National Microbial Pathogen Data Resource, Chicago, Illinois3

Received 16 August 2006/ Returned for modification 21 October 2006/ Accepted 14 December 2006

Vibrio cholerae NRT36S is a non-cholera toxin-producing, non-O1 strain that causes diarrhea in volunteers. The genome of NRT36S was sequenced to create a draft containing 174 contigs plus the superintegron region. Our analysis of the draft genome revealed several putative toxin genes and colonization factors. Besides confirming the existence of nonagglutinable heat-stable toxin, we also identified the genes for a type three secretion system, a putative exotoxin, two different RTX toxins, and four pilus systems.

* Corresponding author. Mailing address: University of Maryland, Howard Hall 585, 660 W. Redwood Street, Baltimore, MD 21201. Phone: (410) 706-1607. Fax: (410) 706-1644. E-mail: ostin001{at}umaryland.edu

{triangledown} Published ahead of print on 5 February 2007.

Editor: A. Camilli

Infection and Immunity, May 2007, p. 2645-2647, Vol. 75, No. 5
0019-9567/07/$08.00+0     doi:10.1128/IAI.01317-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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