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Infection and Immunity, June 2007, p. 2991-2995, Vol. 75, No. 6
0019-9567/07/$08.00+0     doi:10.1128/IAI.01741-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Pathogenic Implication of a Fibrinogen-Binding Protein of Staphylococcus epidermidis in a Rat Model of Intravascular-Catheter-Associated Infection

Beining Guo, Xu Zhao, Yaoguo Shi, Demei Zhu, and Yingyuan Zhang^*

Institute of Antibiotics, Huashan Hospital, No. 12 Wulumuqi Zhong Road, Shanghai 200040, China

Received 31 October 2006/ Returned for modification 13 December 2006/ Accepted 18 March 2007

The involvement of Fbe, a fibrinogen-binding protein of Staphylococcus epidermidis, in the pathogenesis of catheter-associated infection was investigated. An fbe (gene encoding Fbe protein) mutant was constructed by allelic replacement, wherein an erythromycin resistance gene replaced a portion of the A region of fbe. Meanwhile, a rat central venous catheter (CVC) infection model was established to assess the importance of Fbe in the pathogenesis of CVC-associated infection due to S. epidermidis. Fbe-positive S. epidermidis strain HB was significantly more likely to cause a CVC-associated infection resulting in bacteremia and metastatic disease than its isogenic Fbe-deficient mutant (100% versus 20%, P < 0.01). These results confirm the importance of adherence associated with Fbe in the pathogenesis of CVC-associated infection caused by S. epidermidis.

Published ahead of print on 26 March 2007.

Editor: J. B. Bliska

B.G. and X.Z. contributed equally to this work.

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