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Infection and Immunity, June 2007, p. 3197-3201, Vol. 75, No. 6
0019-9567/07/$08.00+0     doi:10.1128/IAI.01611-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Strain-Dependent Variation in Mycobacterium bovis BCG-Induced Human T-Cell Activation and Gamma Interferon Production In Vitro{triangledown}

Ana M. Aguirre-Blanco,1,{dagger} Pauline T. Lukey,2 Jacqueline M. Cliff,1* and Hazel M. Dockrell1

Department of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom,1 GlaxoSmithKline R&D, Stevenage, United Kingdom2

Received 5 October 2006/ Returned for modification 18 December 2006/ Accepted 14 March 2007

Three commonly used Mycobacterium bovis BCG vaccine strains elicited different magnitudes of T-cell activation and gamma interferon production in vitro in healthy BCG-vaccinated individuals. Glaxo 1077 exhibited the greatest stimulatory capacity, followed by Pasteur 1173 and then Danish 1331. These differences may affect in vitro stimulation and vaccination-induced immunogenicity.

* Corresponding author. Mailing address: Department of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom. Phone: 44(0)207 612 7833. Fax: 44(0)207 637 4314. E-mail: jackie.cliff{at}lshtm.ac.uk

{triangledown} Published ahead of print on 26 March 2007.

Editor: J. L. Flynn

{dagger} Present address: Institute of Cell and Molecular Science, Queen Mary's School of Medicine and Dentistry, London, United Kingdom.

Infection and Immunity, June 2007, p. 3197-3201, Vol. 75, No. 6
0019-9567/07/$08.00+0     doi:10.1128/IAI.01611-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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