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Infection and Immunity, July 2007, p. 3425-3433, Vol. 75, No. 7
0019-9567/07/$08.00+0     doi:10.1128/IAI.00050-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Genome Sequence of a Clinical Isolate of Campylobacter jejuni from Thailand ^,

Enteric Diseases,¹ Biological Defense Research Directorates, Naval Medical Research Center, Silver Spring, Maryland,² Food and Drug Administration, Beltsville, Maryland³

Received 10 January 2007/ Returned for modification 16 March 2007/ Accepted 4 April 2007

Campylobacter jejuni CG8486, which belongs to the HS4 complex, was isolated from a patient with inflammatory diarrhea in Thailand. This strain caused a diarrheal disease in ferrets comparable to that caused by C. jejuni strain 81-176, but it was much less invasive for epithelial cells in vitro than 81-176. Complete genome sequencing of CG8486 revealed a 1.65-Mb genome that was very similar to the other two published genomes of clinical isolates of C. jejuni, the genomes of 81-176 and NCTC 11168, with a limited number of CG8486-specific genes mapping outside the hypervariable carbohydrate biosynthesis loci. These data suggest that the genes required for induction of inflammatory diarrhea are among the genes shared by CG8486 and 81-176 but that either major changes in the carbohydrate loci and/or more subtle changes in other genes may modulate virulence.

Published ahead of print on 16 April 2007.

Supplemental material for this article may be found at http://iai.asm.org/.

Editor: V. J. DiRita

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