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Infection and Immunity, July 2007, p. 3556-3560, Vol. 75, No. 7
0019-9567/07/$08.00+0     doi:10.1128/IAI.00086-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Memory CD4 T Cells Enhance Primary CD8 T-Cell Responses{triangledown}

Connie M. Krawczyk,1,2 Hao Shen,2* and Edward J. Pearce1*

Department of Pathobiology, School of Veterinary Medicine,1 Department of Microbiology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 191042

Received 15 January 2007/ Returned for modification 23 February 2007/ Accepted 5 April 2007

CD4 T-cell help is required for optimal memory CD8 T-cell responses. We have found that engaging preexisiting CD4 Th1, but not Th2, memory cells at the time of CD8 T-cell priming results in increased CD8 effector responses to both bacterial and viral pathogens. The enhanced responses are characterized by increased numbers of cytokine-producing, antigen-specific cells. These findings suggest that engaging endogenous memory Th1 cells may increase cellular responses in an immunotherapy or vaccination setting.

* Corresponding author. Mailing address for Edward J. Pearce: Department of Pathobiology, Room 318 Hill Pavilion, School of Veterinary Medicine, 380 South University Avenue, Philadelphia, PA 19104-4539. Phone: (215) 573-3493. Fax: (215) 746-2295. E-mail: ejpearce{at}mail.med.upenn.edu. Mailing address for Hao Shen: Department of Medicine, Room 303C Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104-6076. Phone: (215) 573-5259. Fax: (215) 573-9068. E-mail: hshen{at}mail.med.upenn.edu

{triangledown} Published ahead of print on 16 April 2007.

Editor: J. L. Flynn

Infection and Immunity, July 2007, p. 3556-3560, Vol. 75, No. 7
0019-9567/07/$08.00+0     doi:10.1128/IAI.00086-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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