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Infection and Immunity, July 2007, p. 3680-3682, Vol. 75, No. 7
0019-9567/07/$08.00+0     doi:10.1128/IAI.01840-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Fungicidal Monoclonal Antibody C7 Binds to Candida albicans Als3{triangledown}

Sonia Brena,1 Miren J. Omaetxebarría,1 Natalia Elguezabal,1 Jonathan Cabezas,1 María D. Moragues,2 and José Pontón1*

Departamento de Inmunología, Microbiología y Parasitología, Facultad de Medicina y Odontología,1 Departamento de Enfermería I, Universidad del País Vasco, Bilbao, Vizcaya, Spain2

Received 21 November 2006/ Returned for modification 3 December 2006/ Accepted 15 April 2007

Monoclonal antibody (MAb) C7 reacted with a >200-kDa component from the Candida albicans cell wall identified by matrix-assisted laser desorption ionization-time-of-flight mass spectrometry as Als3. It also bound the recombinant N terminus of Als3. Binding of MAb C7 to Als3 may explain the biological activities exerted by the MAb on C. albicans.

* Corresponding author. Mailing address: Departamento de Inmunología, Microbiología y Parasitología, Facultad de Medicina y Odontología, Universidad del País Vasco, Apartado 699, E-48080 Bilbao, Vizcaya, Spain. Phone: 34 94-601-2855. Fax: 34 94-601-3495. E-mail: jose.ponton{at}ehu.es

{triangledown} Published ahead of print on 23 April 2007.

Editor: A. Casadevall

Infection and Immunity, July 2007, p. 3680-3682, Vol. 75, No. 7
0019-9567/07/$08.00+0     doi:10.1128/IAI.01840-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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