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Infection and Immunity, July 2007, p. 3683-3685, Vol. 75, No. 7
0019-9567/07/$08.00+0     doi:10.1128/IAI.01721-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

PorA Variable Antigenic Regions VR1, VR2, and VR3 of Neisseria meningitidis Serogroups B and C Isolated in Brazil from 1999 to 2004{triangledown}

Ivano de Filippis,1,2* Claudia Ferreira de Andrade,1 Luciete Silva,3 D. Rebecca Prevots,2 and Ana Carolina P. Vicente4

National Institute for Quality Control of Health, Oswaldo Cruz Foundation, Rio de Janeiro 21045-900, Brazil,1 National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892,2 Leonidas and Maria Deane Research Center, Oswaldo Cruz Foundation, 69057-070 Manaus, Brazil,3 Genetics Department, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro 21045-900, Brazil4

Received 26 October 2006/ Returned for modification 24 January 2007/ Accepted 2 May 2007

The high genetic diversity found among the PorA regions VR1 and VR2 of 101 Neisseria meningitidis isolates from patients with meningococcal disease and healthy carriers in Brazil contrasts with the stability found in the PorA VR3 of these isolates. The presence of VR3 epitope variant 35 or 36 on the surfaces of 87% of the strains analyzed suggests that these antigens should be considered for inclusion in new formulations of vaccines against serogroup B meningococci in Brazil.

* Corresponding author. Mailing address: Fundacao Oswaldo Cruz, INCQS, Av. Brasil, 4365, Manguinhos, Rio de Janeiro 21045-900, Brazil. Phone: 55-21-3865-5236. Fax: 55-21-2290-0915. E-mail: ivano.defilippis{at}incqs.fiocruz.br

{triangledown} Published ahead of print on 14 May 2007.

Editor: V. J. DiRita

Infection and Immunity, July 2007, p. 3683-3685, Vol. 75, No. 7
0019-9567/07/$08.00+0     doi:10.1128/IAI.01721-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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