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Infection and Immunity, August 2007, p. 3859-3867, Vol. 75, No. 8
0019-9567/07/$08.00+0     doi:10.1128/IAI.00159-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Heterogeneity of a Campylobacter jejuni Protein That Is Secreted through the Flagellar Filament{triangledown}

Frédéric Poly, Cheryl Ewing, Scarlett Goon, Thomas E. Hickey, David Rockabrand, Gary Majam, Lanfong Lee, Julie Phan, Nicholas J. Savarino, and Patricia Guerry*

Enteric Diseases Department, Naval Medical Research Center, Silver Spring, Maryland 20910

Received 30 January 2007/ Returned for modification 12 March 2007/ Accepted 13 May 2007

Cj0859c, or FspA, is a small, acidic protein of Campylobacter jejuni that is expressed by a {sigma}28 promoter. Analysis of the fspA gene in 41 isolates of C. jejuni revealed two overall variants of the predicted protein, FspA1 and FspA2. Secretion of FspA occurs in broth-grown bacteria and requires a minimum flagellar structure. The addition of recombinant FspA2, but not FspA1, to INT407 cells in vitro resulted in a rapid induction of apoptosis. These data define a novel C. jejuni virulence factor, and the observed heterogeneity among fspA alleles suggests alternate virulence potential among different strains.

* Corresponding author. Mailing address: Enteric Diseases Department, Naval Medical Research Center, 503 Robert Grant Ave., Silver Spring, MD 20910. Phone: (301) 319-7662. Fax: (301) 319-7679. E-mail: guerryp{at}nmrc.navy.mil

{triangledown} Published ahead of print on 21 May 2007.

Editor: A. Camilli

Infection and Immunity, August 2007, p. 3859-3867, Vol. 75, No. 8
0019-9567/07/$08.00+0     doi:10.1128/IAI.00159-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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