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Amended Description of the Genes for Synthesis of Actinomyces naeslundii T14V Type 1 Fimbriae and Associated Adhesin ^,

Microbiology Branch, U.S. Army Dental and Trauma Research Detachment, Walter Reed Army Institute of Research, Great Lakes, Illinois 60088,¹ Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research,² Proteomics and Mass Spectrometry Facility, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892³

Received 13 December 2006/ Returned for modification 6 January 2007/ Accepted 29 April 2007

The type 1 fimbriae of Actinomyces naeslundii T14V mediate adhesion of this gram-positive species to the tooth surface. The present findings show that the locus for type 1 fimbria production in this strain includes three genes, fimQ for a minor fimbrial subunit that appears to be an adhesin, fimP for the major structural subunit, and srtC1 for a type 1 fimbria-specific sortase involved in the assembly of these structures.

Published ahead of print on 7 May 2007.

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Editor: A. Camilli