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Infection and Immunity, September 2007, p. 4528-4533, Vol. 75, No. 9
0019-9567/07/$08.00+0     doi:10.1128/IAI.00603-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Mutation of traP in Staphylococcus aureus Has No Impact on Expression of agr or Biofilm Formation{triangledown}

Laura H. Tsang, Sonja T. Daily, Elizabeth C. Weiss, and Mark S. Smeltzer*

Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, 4301 W. Markham, Little Rock, Arkansas 72205

Received 27 April 2007/ Returned for modification 14 May 2007/ Accepted 25 May 2007

To investigate the regulatory role of traP (target of RNAIII-activating peptide) in Staphylococcus aureus, we generated traP mutations in the clinical isolates UAMS-1 and USA300. In neither case did mutation of traP affect expression of the accessory gene regulator (agr) or the ability to form a biofilm. We were also unable to confirm that mutation of traP in the prototype 8325-4 laboratory strain RN6390 results in reduced expression of agr, reduced hemolytic activity, or an altered capacity to form a biofilm.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, 4301 W. Markham, Mail Slot 511, Little Rock, AR 72205. Phone: (501) 686-7958. Fax: (501) 686-5359. E-mail: smeltzermarks{at}uams.edu

{triangledown} Published ahead of print on 4 June 2007.

Editor: J. B. Bliska

Infection and Immunity, September 2007, p. 4528-4533, Vol. 75, No. 9
0019-9567/07/$08.00+0     doi:10.1128/IAI.00603-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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