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Infection and Immunity, January 2008, p. 298-307, Vol. 76, No. 1
0019-9567/08/$08.00+0     doi:10.1128/IAI.00866-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Global Transcriptome Analysis of Borrelia burgdorferi during Association with Human Neuroglial Cells{triangledown} ,{dagger}

Jill A. Livengood, Virginia L. Schmit, and Robert D. Gilmore Jr.*

National Center for Zoonotic, Vector-Borne, and Enteric Diseases, Division of Vector-Borne Infectious Diseases, Bacterial Diseases Branch, Centers for Disease Control and Prevention, Fort Collins, Colorado 80521

Received 26 June 2007/ Returned for modification 4 October 2007/ Accepted 24 October 2007

As adherence and entry of a pathogen into a host cell are key components to an infection, identifying the molecular mechanisms responsible for cellular association will provide a better understanding of a microbe's pathogenesis. We previously established an in vitro model for Borrelia burgdorferi infection of human neuroglial cells. To expand on our earlier study, we performed B. burgdorferi whole-genome expression analysis following a 20-hour infection of human neuroglial cells to identify borrelial genes that were differentially regulated during host-cell association compared with cultured Borrelia in cell-free medium. This study identifies several regulated genes, the products of which may be important mediators of cellular pathogenesis.

* Corresponding author. Mailing address: Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, 3150 Rampart Road, CSU Foothills Campus, Fort Collins, CO 80521. Phone: (970) 221-6405. Fax: (970) 221-6476. E-mail: rbg9{at}cdc.gov

{triangledown} Published ahead of print on 5 November 2007.

{dagger} Supplemental material for this article may be found at http://iai.asm.org/.

Editor: A. Camilli

Infection and Immunity, January 2008, p. 298-307, Vol. 76, No. 1
0019-9567/08/$08.00+0     doi:10.1128/IAI.00866-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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  • Hughes, J. L., Nolder, C. L., Nowalk, A. J., Clifton, D. R., Howison, R. R., Schmit, V. L., Gilmore, R. D. Jr., Carroll, J. A. (2008). Borrelia burgdorferi Surface-Localized Proteins Expressed during Persistent Murine Infection Are Conserved among Diverse Borrelia spp.. Infect. Immun. 76: 2498-2511 [Abstract] [Full Text]  


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