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Infection and Immunity, January 2008, p. 97-102, Vol. 76, No. 1
0019-9567/08/$08.00+0     doi:10.1128/IAI.00982-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Use of a Genetically Engineered Strain To Evaluate the Pathogenic Potential of Yeast Cell and Filamentous Forms during Candida albicans Systemic Infection in Immunodeficient Mice{triangledown}

Stephen P. Saville,1 Anna L. Lazzell,1 Ashok K. Chaturvedi,1 Carlos Monteagudo,2 and Jose L. Lopez-Ribot1*

Department of Biology, The University of Texas at San Antonio, San Antonio, Texas,1 Departmento de Patología, Universidad de Valencia, Facultad de Medicina y Odontología, Valencia, Spain2

Received 18 July 2007/ Returned for modification 17 August 2007/ Accepted 17 October 2007

The pathogenesis of Candida albicans systemic infection is complex and results from the balance between its intrinsic virulence attributes and the host immune responses. Morphogenetic transitions between yeast cell and filamentous forms are considered one of the main virulence attributes in C. albicans. We have examined the pathogenesis of a genetically engineered C. albicans strain in which morphogenetic conversions can be externally manipulated in immunodeficient mice; these included B-cell deficient, nude (T cell deficient), SCID (lacking both functional T and B cells), and DBA/2N (C5 deficient with impaired neutrophil activity) mice. We also tested mice severely immunosuppressed by cyclophosphamide-cortisone acetate treatment. Mice with specific immune defects were able to survive an infection by yeast cells but not filamentous forms. However, yeast cells displayed a pathogenic effect leading to lethality in the severely immunosuppressed mice.

* Corresponding author. Mailing address: Department of Biology, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249. Phone: (210) 458-7022. Fax: (210) 458-7023. E-mail: jose.lopezribot{at}utsa.edu

{triangledown} Published ahead of print on 29 October 2007.

Editor: A. Casadevall

Infection and Immunity, January 2008, p. 97-102, Vol. 76, No. 1
0019-9567/08/$08.00+0     doi:10.1128/IAI.00982-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Saville, S. P., Lazzell, A. L., Chaturvedi, A. K., Monteagudo, C., Lopez-Ribot, J. L. (2009). Efficacy of a Genetically Engineered Candida albicans tet-NRG1 Strain as an Experimental Live Attenuated Vaccine against Hematogenously Disseminated Candidiasis. CVI 16: 430-432 [Abstract] [Full Text]  


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