IAI FigSearch
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Other Versions of this Article:
IAI.00647-07v1
76/5/2177    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Google Scholar
Right arrow Articles by Harvill, E. T.
Right arrow Articles by Merkel, T. J.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Harvill, E. T.
Right arrow Articles by Merkel, T. J.
Infection and Immunity, May 2008, p. 2177-2182, Vol. 76, No. 5
0019-9567/08/$08.00+0     doi:10.1128/IAI.00647-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Anamnestic Protective Immunity to Bacillus anthracis Is Antibody Mediated but Independent of Complement and Fc Receptors{triangledown}

Eric T. Harvill,1 Manuel Osorio,2 Crystal L. Loving,2 Gloria M. Lee,2 Vanessa K. Kelly,2 and Tod J. Merkel2*

Department of Veterinary and Biomedical Science, The Pennsylvania State University, 115 Henning Building, University Park, Pennsylvania 16802,1 Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, 8800 Rockville Pike, Bethesda, Maryland 208922

Received 9 May 2007/ Returned for modification 14 September 2007/ Accepted 15 February 2008

The threat of bioterrorist use of Bacillus anthracis has focused urgent attention on the efficacy and mechanisms of protective immunity induced by available vaccines. However, the mechanisms of infection-induced immunity have been less well studied and defined. We used a combination of complement depletion along with immunodeficient mice and adoptive transfer approaches to determine the mechanisms of infection-induced protective immunity to B. anthracis. B- or T-cell-deficient mice lacked the complete anamnestic protection observed in immunocompetent mice. In addition, T-cell-deficient mice generated poor antibody titers but were protected by the adoptive transfer of serum from B. anthracis-challenged mice. Adoptively transferred sera were protective in mice lacking complement, Fc receptors, or both, suggesting that they operate independent of these effectors. Together, these results indicate that antibody-mediated neutralization provides significant protection in B. anthracis infection-induced immunity.

* Corresponding author. Mailing address: Laboratory of Respiratory and Special Pathogens, DBPAP/CBER/FDA, Bldg. 29, Rm. 418, 29 Lincoln Dr., Bethesda, MD 20892. Phone: (301) 496-5564. Fax: (301) 402-2776. E-mail: tod.merkel{at}fda.hhs.gov

{triangledown} Published ahead of print on 3 March 2008.

Editor: V. J. DiRita

Infection and Immunity, May 2008, p. 2177-2182, Vol. 76, No. 5
0019-9567/08/$08.00+0     doi:10.1128/IAI.00647-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
J. Bacteriol. J. Virol. Eukaryot. Cell
Microbiol. Mol. Biol. Rev. Clin. Vaccine Immunol. All ASM Journals

Copyright © 2008 by the American Society for Microbiology. All rights reserved.