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Infection and Immunity, September 2008, p. 4000-4008, Vol. 76, No. 9
0019-9567/08/$08.00+0     doi:10.1128/IAI.00516-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Genome of Mycoplasma arthritidis{triangledown} ,{dagger}

Kevin Dybvig,* Cao Zuhua, Ping Lao, David S. Jordan, C. Todd French,§ Anh-Hue T. Tu, and Ann E. Loraine{ddagger}

Department of Genetics, University of Alabama Birmingham, Birmingham, Alabama 35294

Received 25 April 2008/ Returned for modification 28 May 2008/ Accepted 10 June 2008

The genomes of several species of mycoplasma have been sequenced. Most of these species rely on the glycolytic pathway for energy production, with the one exception of Ureaplasma, a species that breaks down urea as its principle source of acquiring energy. Several species, including as Mycoplasma arthritidis, are nonglycolytic and can use arginine as their source of energy. Described here are the genome sequence and a transposon library of M. arthritidis. The genome of 820,453 bp is typical in size for a mycoplasma and contains two large families of genes that are predicted to code for phase-variable proteins. The transposon library was constructed using a minitransposon that inserts stably into the mycoplasma genome. Of the 635 predicted coding regions, 218 were disrupted in a library of 1,100 members. Dispensable genes included the gene coding for the MAM superantigen and genes coding for ribosomal proteins S15, S18, and L15.

* Corresponding author. Mailing address: Department of Genetics, University of Alabama at Birmingham, KAUL 720, Birmingham, AL 35294-0024. Phone: (205) 934-9327. Fax: (205) 975-4418. E-mail: dybvig{at}uab.edu

{triangledown} Published ahead of print on 23 June 2008.

{dagger} Supplemental material for this article may be found at http://iai.asm.org/.

Editor: A. Camilli

§ Present address: Department of Microbiology Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095.

Present address: Biology Department, Georgia Southwestern State University, Americus, GA 31709.

{ddagger} Present address: Bioinformatics Research Center, University of North Carolina at Charlotte, Charlotte, NC 28223.

Infection and Immunity, September 2008, p. 4000-4008, Vol. 76, No. 9
0019-9567/08/$08.00+0     doi:10.1128/IAI.00516-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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  • Luo, W., Yu, H., Cao, Z., Schoeb, T. R., Marron, M., Dybvig, K. (2008). Association of Mycoplasma arthritidis Mitogen with Lethal Toxicity but Not with Arthritis in Mice. Infect. Immun. 76: 4989-4998 [Abstract] [Full Text]  


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