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Infection and Immunity, September 2008, p. 4088-4091, Vol. 76, No. 9
0019-9567/08/$08.00+0     doi:10.1128/IAI.00490-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Accelerated Control of Visceral Leishmania donovani Infection in Interleukin-6-Deficient Mice{triangledown}

Henry W. Murray*

Department of Medicine, Weill Cornell Medical College, New York, New York 10065

Received 21 April 2008/ Returned for modification 1 June 2008/ Accepted 12 June 2008

In patients with visceral leishmaniasis, increased levels of circulating interleukin-6 (IL-6) regularly accompany fully expressed, progressive infections (kala-azar). To experimentally test the role of IL-6, responses to an intracellular Leishmania donovani infection in the livers of IL-6–/– and wild-type mice were compared. IL-6–/– mice showed an enhanced control of the infection and earlier, rapid parasite killing along with additional evidence of a stimulated antileishmanial Th1-cell-type response: increased levels of circulating gamma interferon, accelerated granuloma assembly, and heightened responsiveness to chemotherapy. In this model of visceral leishmaniasis, IL-6 appears to act in a suppressive, macrophage-deactivating fashion, which identifies it as a potential target for therapeutic blockade.

* Mailing address: 1300 York Avenue, New York, NY 10065. Phone: (212) 746-6330. Fax: (212) 746-6332. E-mail: hwmurray{at}med.cornell.edu

{triangledown} Published ahead of print on 23 June 2008.

Editor: W. A. Petri, Jr.

Infection and Immunity, September 2008, p. 4088-4091, Vol. 76, No. 9
0019-9567/08/$08.00+0     doi:10.1128/IAI.00490-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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