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Infection and Immunity, December 2009, p. 5428-5436, Vol. 77, No. 12
0019-9567/09/$08.00+0     doi:10.1128/IAI.00528-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Characterization of a Campylobacter jejuni VirK Protein Homolog as a Novel Virulence Determinant{triangledown} ,{dagger}

Veronica Novik, Dirk Hofreuter,{ddagger} and Jorge E. Galán*

Section of Microbial Pathogenesis, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Ave., New Haven, Connecticut 06536

Received 13 May 2009/ Returned for modification 27 July 2009/ Accepted 9 September 2009

Campylobacter jejuni is a leading cause of food-borne illness in the United States. Despite significant recent advances, its mechanisms of pathogenesis are poorly understood. A unique feature of this pathogen is that, with some exceptions, it lacks homologs of known virulence factors from other pathogens. Through a genetic screen, we have identified a C. jejuni homolog of the VirK family of virulence factors, which is essential for antimicrobial peptide resistance and mouse virulence.

* Corresponding author. Mailing address: Section of Microbial Pathogenesis, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Ave., BCMM 354E, New Haven, CT 06536. Phone: (203) 737-2404. Fax: (203) 737-2630. E-mail: jorge.galan{at}yale.edu

{triangledown} Published ahead of print on 21 September 2009.

{dagger} Supplemental material for this article may be found at http://iai.asm.org/.

Editor: V. J. DiRita

{ddagger} Present address: MHH Hannover Medical School, Institute for Medical Microbiology and Hospital Epidemiology, Carl-Neuberg-Strasse 1, D-30625 Hannover, Germany.

Infection and Immunity, December 2009, p. 5428-5436, Vol. 77, No. 12
0019-9567/09/$08.00+0     doi:10.1128/IAI.00528-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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