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Infection and Immunity, February 2009, p. 817-824, Vol. 77, No. 2
0019-9567/09/$08.00+0 doi:10.1128/IAI.01063-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.
Effect of Plasmodium yoelii Exposure on Vaccination with the 19-Kilodalton Carboxyl Terminus of Merozoite Surface Protein 1 and Vice Versa and Implications for the Application of a Human Malaria Vaccine
Jiraprapa Wipasa,1,2,
Huji Xu,1,3,*
Xueqin Liu,1
Chakrit Hirunpetcharat,4
Anthony Stowers,5 and
Michael F. Good1*
The Queensland Institute of Medical Research, P.O. Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia,1 Research Institute for Health Sciences, Chiang Mai University, Chiang Mai 50200, Thailand,2 Changzheng Hospital, the Second Military Medical University, 415 Fengyang Road, Shanghai 200003, People's Republic of China,3 Department of Microbiology, Faculty of Public Health, Mahidol University, Bangkok 10400, Thailand,4 Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 208925
Received 27 August 2008/ Returned for modification 4 October 2008/ Accepted 8 November 2008
It is well known that exposure to one antigen can modulate the immune responses that develop following exposure to closely related antigens. It is also known that the composition of the repertoire can be skewed to favor epitopes shared between a current infection and a preceding one, a phenomenon referred to as "original antigenic sin." It was of interest, therefore, to investigate the antibody response that develops following exposure to the malaria vaccine candidate homologue Plasmodium yoelii MSP119 in mice that had previously experienced malaria infection and vice versa. In this study, preexposure of mice to Plasmodium yoelii elicited native anti-MSP119 antibody responses, which could be boosted by vaccination with recombinant MSP119. Likewise, infection of MSP119-primed mice with P. yoelii led to an increase of anti-MSP119 antibodies. However, this increase was at the expense of antibodies to parasite determinants other than MSP119. This change in the balance of antibody specificities significantly affected the ability of mice to withstand a subsequent infection. These data have particular relevance to the possible outcome of malaria vaccination for those situations where the vaccine response is suboptimal and suggest that suboptimal vaccination may in fact render the ultimate acquisition of natural immunity more difficult.
* Corresponding author. Mailing address for Michael F. Good: Queensland Institute of Medical Research, P.O. Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia. Phone: 61-7-33620203. Fax: 61-7-33620110. E-mail: Michael.Good{at}qimr.edu.au. Mailing address for Huji Xu: Dept. of Rheumatology and Immunology, Changzheng Hospital, the Second Military Medical University, 415 Fengyang Road, Shanghai 200003, People's Republic of China. Phone: 86-21-63519841. Fax: 86-21-63519841. E-mail: Huji.Xu{at}qimr.edu.au
Published ahead of print on 17 November 2008.
These authors contributed equally to this work.
Infection and Immunity, February 2009, p. 817-824, Vol. 77, No. 2
0019-9567/09/$08.00+0 doi:10.1128/IAI.01063-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.
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