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Infection and Immunity, April 2009, p. 1483-1491, Vol. 77, No. 4
0019-9567/09/$08.00+0     doi:10.1128/IAI.01069-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Genetic Polymorphisms of Mannose-Binding Lectin Do Not Influence Placental Malaria but Are Associated with Preterm Deliveries{triangledown}

Audrey D. Thévenon,1 Rose G. F. Leke,2 Amorsolo L. Suguitan Jr.,1,{dagger} James A. Zhou,3 and Diane Wallace Taylor1*

Department of Biology, Georgetown University, Washington, DC,1 Faculty of Medicine and Biomedical Research, University of Yaoundé 1, Yaoundé, Cameroon,2 AZ DataClinic, Inc., Rockville, Maryland3

Received 27 August 2008/ Returned for modification 4 October 2008/ Accepted 30 December 2008

During pregnancy, Plasmodium falciparum-infected erythrocytes (IE) sequester in the placenta where they induce pathology and increase the risk of low-birth-weight (LBW) babies. The innate immune mediator, mannose-binding lectin (MBL), enhances phagocytosis of pathogens. Since MBL is reported to bind to IE, we hypothesized that it might aid in clearance of IE from the placenta, thereby reducing the risk of LBW babies. To test this hypothesis, molecular genotyping was used to detect polymorphisms at codon 57 (A/C) in exon 1 of MBL2 in 401 pregnant Cameroonian women, with or without placental malaria, who had LBW and normal-weight babies. Polymorphisms in the promoter region at positions –550 (H/L), –221 (X/Y), and +4 (P/Q) were also determined, and plasma MBL levels were measured during pregnancy and at delivery. The expected correlation between genotype and plasma MBL levels was confirmed. However, asymptomatic infections were not associated with an increase in MBL levels in the peripheral blood, and MBL levels were similar in the placental and cord blood of women with or without placental malaria at delivery. There was no evidence that MBL levels at delivery were associated with malaria-related poor pregnancy outcomes. Women with the LXPA haplotype, however, were more likely to have LBW babies, but the risk was not related to malaria. These results do not support the hypothesis that MBL aids in the clearance of parasites from the placenta but suggest that Cameroonian women with LXPA are at risk of having LBW babies due to other causes.

* Corresponding author. Present address: Department of Tropical Medicine, Medical Microbiology, and Pharmacology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813. Phone: (808) 692-1608. Fax: (808) 692-1979. E-mail: dwtaylor{at}hawaii.edu

{triangledown} Published ahead of print on 12 January 2009.

Editor: W. A. Petri, Jr.

{dagger} Present address: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.

Infection and Immunity, April 2009, p. 1483-1491, Vol. 77, No. 4
0019-9567/09/$08.00+0     doi:10.1128/IAI.01069-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.



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