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Infect Immun. 1973 October; 8(4): 573-576
Copyright © 1973 American Society for Microbiology. All Rights Reserved.

Influence of Histones on the Antibody Response in Guinea Pigs to Vaccination with A/Aichi/2/68 (H3 N2) Influenza Virus

Institute of Virology, Medizinische Hochschule Hannover, Hannover-Kleefeld
Department of Microbiology, Technische Hochschule Aachen, Aachen, Germany

ABSTRACT

The influence of total, F1, and F3 histones on the primary antibody response in guinea pigs to vaccination with influenza virus A/2/Aichi/2/68 (H3 N2) was investigated. It was found that histones can greatly reduce the immunoglobulin (Ig) M and, to a smaller degree, the IgG antibody response. The immunosuppressive effect of histones was found to depend critically on the dose of virus used for vaccination, on the type and dose of histones, and on the schedule of histone application.