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Infect Immun. 1973 October; 8(4): 650-656
Copyright © 1973 American Society for Microbiology. All Rights Reserved.

Immunity Against Parainfluenza-3 Virus in Cattle: Anti-Neuraminidase Activity in Serum and Nasal Secretion

Institute of Virology, Royal Veterinary College and National Veterinary Institute, Stockholm
Wallenberg Laboratory, University of Uppsala, Uppsala, Sweden

ABSTRACT

The antigenicity of two parainfluenza=3 virus strains, a "neuraminidasestrong" and a "neuraminidase-weak," was compared. For both strains the amount of hemagglutinin units was equal. The antibody responses to neuraminidase and hemagglutinin were measured on samples of serum and nasal secretion and were found to be similar, irrespective of the strain used for immunization. Anti-neuraminidase activity was demonstrated in the gel phase of nasal secretion of immunized cattle. Immunglobulin A was found attached to the peplomers of inhibited virus by immuno-electron microscopy.