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Infect Immun. 1973 November; 8(5): 814-818
Copyright © 1973 American Society for Microbiology. All Rights Reserved.

Polyarthritis Associated with Salmonella Infection in Rats

Alvin Volkman and Frank M. Collins

1 Trudeau Institute, Inc., Saranac Lake, New York 12983

ABSTRACT

Rats infected intravenously with Salmonella enteritidis develop a chronic destructive polyarthritis. The joint lesions resemble those of human rheumatoid arthritis in distribution and pathology. On the basis of histological and microbiological studies, involvement does not appear to be the result of intra-articular sepsis. Instead, the data favor the view that transient infection incites an immunological response that localizes in the joint and becomes destructive.

Infect Immun. 1973 November; 8(5): 814-818
Copyright © 1973 American Society for Microbiology. All Rights Reserved.





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Copyright © 1973 by the American Society for Microbiology. All rights reserved.