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Infect Immun. 1973 December; 8(6): 969-976
Copyright © 1973 American Society for Microbiology. All Rights Reserved.

Filamentous Capsulated Streptococci from the Human Respiratory Tract III. Immunochemical Studies of the Cross-Reactivity Between the Cell Wall Antigens of a Filamentous Streptococcus and of Pneumococcus

Walter W. Karakawa, Judith A. Kane and Robert Austrian

1 Departments of Research Medicine and Microbiology, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19174

ABSTRACT

A cell wall-associated polysaccharide has been isolated from a noncapsulated mutant, 89R50, of the alpha-hemolytic filamentous streptococcus of provisional capsular type 89. Chemical analysis of the polysaccharide indicates that it consists of galactosamine, glucosamine, glucose, and phosphorus. Immunological cross-reactivity was observed between the streptococcal cell wall antigen and antibody to the cell wall-like capsular polysaccharide of pneumococcus. This cross-reactivity appears attributable to similarities in the teichoic acid moieties rather than in the mucopeptide moieties of the two polymers. No chemical or immunological differences were observed in the cell wall carbohydrate of the noncapsulated streptococcus, 89R50, and that of its capsulated progenitor. It is suggested that antibody to this cell wall polysaccharide might serve as a basis for grouping other filamentous strains of streptococci of diverse capsular types, the cell wall antigens of which show similar cross-reactivity with that of pneumococcus.

Infect Immun. 1973 December; 8(6): 969-976
Copyright © 1973 American Society for Microbiology. All Rights Reserved.





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