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Infect Immun. 1974 May; 9(5): 801-810
Copyright © 1974 American Society for Microbiology. All Rights Reserved.

Leukocytosis-Promoting Factor of Bordetella pertussis III. Its Identity with Protective Antigen

¹ The First Department of Bacteriology and Department of Chemistry, National Institute of Health, Kamiosaki, Shinagawa-ku, Tokyo 141, Japan

ABSTRACT

Leukocytosis-promoting factor (LPF) was purified from the supernatant of a 5-day liquid culture of Bordetella pertussis strains Tohama and no. 134. The preparations appeared to be filamentous molecules (2 by 40 nm) and contained histamine-sensitizing and hemagglutinin activities in addition to leukocytosis-promoting activity. Active protection tests in mice demonstrated strong protective activities of 80 international protective units per mg of protein in LPF preparations of each strain toxoided by mild Formalin treatment. Passive protection tests in mice with anti-LPF sera indicated that anti-LPF is one of the protective antibodies.

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• Congeni, B. L., Orenstein, D. M., Nankervis, G. A. (1978). Three Infants with Neonatal Pertussis: Because of Its Atypical Presentations, Pertussis in the Neonate May Easily Be Overlooked. CLIN PEDIATR 17: 113-118