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Infect Immun. 1974 June; 9(6): 1102-1104
Copyright © 1974 American Society for Microbiology. All Rights Reserved.

Role of Typhoid Antigens in Protection and Pathogenicity for Mice

Division of Bacterial Immunology, Bureau of Research, Laboratory Centre for Disease Control, Ottawa, Ontario, Canada
The Department of Bacterial Immunology, Walter Reed Army Institute of Research, Washington, D.C. 20012

ABSTRACT

Swiss white mice immunized with acetone-killed vaccines prepared from strains of Salmonella typhosa, S. typhimurium, and mouse-virulent S. typhimurium hybrids which had acquired, by conjugal genetic transfer, the S. typhosa antigens 9, Vi, and d were challenged with the S. typhimurium hybrids and with the S. typhimurium parent strain. The results of these experiments suggested that the Salmonella somatic antigens were important in conferring protection against death in this system. The S. typhosa Vi antigen did not appear to play any significant role in this protection. The S. typhimurium hybrids employed in these studies did not show any loss of mouse virulence as the consequence of acquisition of various combinations of the S. typhosa somatic, flagella, or Vi antigens, nor did S. typhosa hybrids which had acquired the somatic antigen of S. typhimurium show any increase in mouse virulence.