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Infect Immun. 1974 June; 9(6): 999-1002
Copyright © 1974 American Society for Microbiology. All Rights Reserved.

Immunological Responses to Candida albicans I. Mouse-Thigh Lesion as a Model for Experimental Candidiasis

¹ Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington 98195
Department of Pathology, School of Medicine, University of Washington, Seattle, Washington 98195

ABSTRACT

A mouse-thigh lesion model for experimental candidiasis is described. A standard inoculum of 5 x 10⁸ yeast cells of Candida albicans, injected into the thigh muscle of C57BL/Ks mice, produced an easily measured thigh lesion that was self-limiting by 4 to 6 weeks, permitting a study of immunological responses to the infection. Examination of the histopathology of the lesion reveals that the cellular infiltrate is predominately granulocytic, and gives little evidence for an active, specific, cell-mediated immune response.

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