Mimotopes of Apical Membrane Antigen 1: Structures of Phage-Derived Peptides Recognized by the Inhibitory Monoclonal Antibody 4G2dc1 and Design of a More Active Analogue
Infect. Immun. Sabo et al.
75: 61
Supplemental material
Files in this Data Supplement:
- Supplemental file 1
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Table S1. Chemical shifts, 3JHNHƒÑ, and backbone amide temperature coefficients of J1 in 90 percent H2O¡X10 percent 2H2O at pH 4.5, and 278 K.
Table S2. Chemical shifts and 3JHNHƒÑ of J1cc in 95 percent H2O¡X5 percent 2H2O with 10 mM sodium acetate at pH 4.5 and 278 K.
Table S3. Chemical shifts, 3JHNHƒÑ, and backbone amide temperature coefficients of J3 in 95 percent H2O¡X5 percent 2H2O with 10 mM acetate at pH 4.5 and 278 K.
Table S4. Chemical shifts, 3JHNHƒÑ, and backbone amide temperature coefficients of J7 in 90 percent H2O¡X10 percent 2H2O at pH 3.7 and 278 K.
Fig. S1. NOE patterns observed in the J1, J1cc, J3, and J7 peptides.
Fig. S2. Angular order parameters (S) for the φ, ψ, and χ1 angles in the final family of structures for peptides J3 and J7.
Fig. S3. Stereo view of the superposition of J7 and the high-mobility group 1 protein over their identical residues and of the superposition of the closest-to-average structure in the J7 family and the model structure of neurotoxin 6 from the Indian cobra.
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