A Chemokine-Degrading Extracellular Protease Made by Group A Streptococcus Alters Pathogenesis by Enhancing Evasion of the Innate Immune Response
Infect. Immun. Sumby et al.
76: 978
Supplemental material
Files in this Data Supplement:
- Supplemental file 1
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Fig. S1. Construction of isogenic spyCEP mutant strains. Fig. S2. Alignment of SpyCEP amino acid sequences from 12 GAS strains representing nine distinct serotypes. Fig. S3. Expression microarray confirmation of spyCEP as the only gene differentially transcribed between MGAS2221 and isogenic mutant 2221&DeltaCEP. Fig. S4. ClustalW alignment of the murine chemokine MIP-2 and the human chemokines IL-8, GCP-2, and GRO&alpha. Fig. S5. Silver-stained gels of IL-8 or GCP-2 samples after incubation with MGAS5005 or 5005&DeltaCEP culture supernatants.
Zipped PPT document, 5.1MB.
- Supplemental file 2
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Legends for supplemental figures.
Word document, 29K.
