This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Metcalf, J F
Right arrow Articles by Reichert, R W
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Metcalf, J F
Right arrow Articles by Reichert, R W

 Previous Article  |  Next Article 

Infect Immun. 1979 December; 26(3): 1164-1171

Herpetic keratitis in athymic (nude) mice.

J F Metcalf, D S Hamilton and R W Reichert

ABSTRACT

The inflammatory response to herpes simplex virus infection of the cornea was studied in athymic nude (nu/nu) and heterozygote (nu/+) BALB/c mice. Although athymic mice were highly susceptible to HSV infection and died 13 to 17 days after corneal inoculation, they failed to develop necrotizing keratitis of the cornea. Heterozygote mice survived the initial virual infection, but many of these mice developed necrotizing keratitis and permanent corneal scarring. Light and electron microscopy showed numerous inflammatory cells (polymorphonuclear leukocytes and lymphocytes) in the corneas of heterozygote mice, but not in the athymic mice. These studies suggest that the immune system plays a dual role in herpes simplex virus infection of the cornea: protection against dissemination of the virus and immunopathogenesis of necrotizing keratitis in the cornea.

Infect Immun. 1979 December; 26(3): 1164-1171




This article has been cited by other articles:

  • Divito, S. J., Hendricks, R. L. (2008). Activated Inflammatory Infiltrate in HSV-1-Infected Corneas without Herpes Stromal Keratitis. IOVS 49: 1488-1495 [Abstract] [Full Text]  
  • Lepisto, A. J., Xu, M., Yagita, H., Weinberg, A. D., Hendricks, R. L. (2007). Expression and function of the OX40/OX40L costimulatory pair during herpes stromal keratitis. J. Leukoc. Biol. 81: 766-774 [Abstract] [Full Text]  
  • Lepisto, A. J., Frank, G. M., Xu, M., Stuart, P. M., Hendricks, R. L. (2006). CD8 T Cells Mediate Transient Herpes Stromal Keratitis in CD4-Deficient Mice.. IOVS 47: 3400-3409 [Abstract] [Full Text]  
  • Biswas, P. S., Banerjee, K., Kim, B., Kinchington, P. R., Rouse, B. T. (2005). Role of Inflammatory Cytokine-Induced Cycloxygenase 2 in the Ocular Immunopathologic Disease Herpetic Stromal Keratitis. J. Virol. 79: 10589-10600 [Abstract] [Full Text]  
  • Banerjee, K., Biswas, P. S., Kumaraguru, U., Schoenberger, S. P., Rouse, B. T. (2004). Protective and Pathological Roles of Virus-Specific and Bystander CD8+ T Cells in Herpetic Stromal Keratitis. J. Immunol. 173: 7575-7583 [Abstract] [Full Text]  
  • Stuart, P. M., Summers, B., Morris, J. E., Morrison, L. A., Leib, D. A. (2004). CD8+ T cells control corneal disease following ocular infection with herpes simplex virus type 1. J. Gen. Virol. 85: 2055-2063 [Abstract] [Full Text]  
  • Stumpf, T. H., Case, R., Shimeld, C., Easty, D. L., Hill, T. J. (2002). Primary herpes simplex virus type 1 infection of the eye triggers similar immune responses in the cornea and the skin of the eyelids. J. Gen. Virol. 83: 1579-1590 [Abstract] [Full Text]  
  • Norose, K., Yano, A., Zhang, X.-M., Blankenhorn, E., Heber-Katz, E. (2002). Mapping of Genes Involved in Murine Herpes Simplex Virus Keratitis: Identification of Genes and Their Modifiers. J. Virol. 76: 3502-3510 [Abstract] [Full Text]  
  • Carr, D. J.J., Härle, P., Gebhardt, B. M. (2001). The Immune Response to Ocular Herpes Simplex Virus Type 1 Infection. Exp. Biol. Med. 226: 353-366 [Abstract] [Full Text]  
  • Stumpf, T. H., Shimeld, C., Easty, D. L., Hill, T. J. (2001). Cytokine Production in a Murine Model of Recurrent Herpetic Stromal Keratitis. IOVS 42: 372-378 [Abstract] [Full Text]  
  • Chang, E., Galle, L., Maggs, D., Estes, D. M., Mitchell, W. J. (2000). Pathogenesis of Herpes Simplex Virus Type 1-Induced Corneal Inflammation in Perforin-Deficient Mice. J. Virol. 74: 11832-11840 [Abstract] [Full Text]  
  • Ghiasi, H., Cai, S., Perng, G.-C., Nesburn, A. B, Wechsler, S. L (2000). Both CD4+ and CD8+ T cells are involved in protection against HSV-1 induced corneal scarring. Br J Ophthalmol 84: 408-412 [Abstract] [Full Text]  
  • Gangappa, S., Deshpande, S. P., Rouse, B. T. (2000). Bystander Activation of CD4+ T Cells Accounts for Herpetic Ocular Lesions. IOVS 41: 453-459 [Abstract] [Full Text]  
  • Sanna, P. P., Deerinck, T. J., Ellisman, M. H. (1999). Localization of a Passively Transferred Human Recombinant Monoclonal Antibody to Herpes Simplex Virus Glycoprotein D to Infected Nerve Fibers and Sensory Neurons In Vivo. J. Virol. 73: 8817-8823 [Abstract] [Full Text]  
  • Maggs, D. J., Chang, E., Nasisse, M. P., Mitchell, W. J. (1998). Persistence of Herpes Simplex Virus Type 1 DNA in Chronic Conjunctival and Eyelid Lesions of Mice. J. Virol. 72: 9166-9172 [Abstract] [Full Text]  
  • Thomas, J., Rouse, B. T. (1998). Immunopathology of Herpetic Stromal Keratitis: Discordance in CD4+ T Cell Function Between Euthymic Host and Reconstituted SCID Recipients. J. Immunol. 160: 3965-3970 [Abstract] [Full Text]  
  • Sciammas, R., Kodukula, P., Tang, Q., Hendricks, R.L., Bluestone, J.A. (1997). T Cell Receptor-{gamma}/{delta} Cells Protect Mice from Herpes Simplex Virus Type 1-induced Lethal Encephalitis. JEM 185: 1969-1975 [Abstract] [Full Text]  
  • Boisjoly, H. M., Woog, J. J., Pavan-Langston, D., Park, N.-H. (1984). Prophylactic Topical Cyclosporine in Experimental Herpetic Stromal Keratitis. Arch Ophthalmol 102: 1804-1807 [Abstract]  
  • Metcalf, J. F. (1980). Protection From Experimental Ocular Herpetic Keratitis by a Heat-Killed Virus Vaccine. Arch Ophthalmol 98: 893-896 [Abstract]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»