IAI FigSearch
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Reinarz, A. B. G.
Right arrow Articles by Sagik, B. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Reinarz, A. B. G.
Right arrow Articles by Sagik, B. P.

 Previous Article  |  Next Article 

Infect Immun. 1971 February; 3(2): 268-273
Copyright © 1971 American Society for Microbiology. All Rights Reserved.

Age-Dependent Resistance of Mice to Sindbis Virus Infection: Viral Replication as a Function of Host Age

A. B. G. Reinarz1, M. G. Broome2 and B. P. Sagik

a Department of Microbiology, The University of Texas at Austin, Austin, Texas 78712

ABSTRACT

The development of resistance of outbred white mice to two plaque size variants of Sindbis virus was studied as a function of host age. A sudden drop in mortality occurred over a 3-day period. As little as 1 plaque-forming unit (PFU) per mouse was lethal in 1-day-old animals, whereas inocula of 109 PFU per mouse failed to produce high mortality in weanlings. A comparison of viral growth kinetics shows that early replication was similar in newborns and weanlings but that after 6 to 8 hr the production rate and, therefore, the maximal viral titer were suppressed in weanlings. The data demonstrate a lethal viral threshold. Titers in excess of this level lead to mortality, whereas those below it allow survival.

FOOTNOTES

1 Predoctoral Fellow, National Institute of General Medical Sciences, National Institutes of Health.

2 Present address: Ohio State University, Columbus, Ohio 43210.

Infect Immun. 1971 February; 3(2): 268-273
Copyright © 1971 American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:



Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
J. Bacteriol. J. Virol. Eukaryot. Cell
Microbiol. Mol. Biol. Rev. Clin. Vaccine Immunol. All ASM Journals

Copyright © 1971 by the American Society for Microbiology. All rights reserved.