This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Shadomy, S. Search for Related Content PubMed PubMed Citation Articles by Shadomy, S.

 Previous Article  |  Next Article 

Infect Immun. 1971 August; 4(2): 143-148
Copyright © 1971 American Society for Microbiology. All Rights Reserved.

In Vitro Antifungal Activity of Clotrimazole (Bay b 5097)

¹ Department of Medicine, Division of Immunology and Infectious Diseases, Medical College of Virginia, The Health Sciences Division, Virginia Commonwealth University, Richmond, Virginia 23219

ABSTRACT

The in vitro antifungal activity of clotrimazole (Bay b 5097) was compared with those of amphotericin B, griseofulvin, nystatin, and pyrrolnitrin. The inhibitory activity of clotrimazole against most systemic pathogens was comparable to that of amphotericin B; minimal inhibitory concentrations of the two drugs for Blastomyces dermatitidis, Histoplasma capsulatum, Sporothrix schenckii, Cryptococcus neoformans, and Coccidioides immitis were in the range of 0.20 to 3.13 and 0.10 to 6.25 µg/ml, respectively. One isolate of Allescheria boydii was resistant to 100 µg of amphotericin B per ml but was inhibited by 6.25 µg of clotrimazole per ml. Clotrimazole was less active than amphotericin B against Candida albicans and Aspergillus fumigatus. The activity of clotrimazole against dermatophytes was comparable to that of pyrrolnitrin; 0.78 µg of either compound per ml was fungicidal for most isolates of Trichophyton sp., Microsporum sp. and Epidermophyton floccosum. Both griseofulvin and nystatin were less active than clotrimazole. The size of inoculum was shown to have a significant effect on the results of in vitro susceptibility testing with clotrimazole.

This article has been cited by other articles:

• Pelletier, R., Peter, J., Antin, C., Gonzalez, C., Wood, L., Walsh, T. J. (2000). Emergence of Resistance of Candida albicans to Clotrimazole in Human Immunodeficiency Virus-Infected Children: In Vitro and Clinical Correlations. J. Clin. Microbiol. 38: 1563-1568 [Abstract] [Full Text]