This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Francis, D H Articles by Duimstra, J R Search for Related Content PubMed PubMed Citation Articles by Francis, D H Articles by Duimstra, J R

 Previous Article  |  Next Article 

Infect Immun. 1986 March; 51(3): 953-956

Infection of gnotobiotic pigs with an Escherichia coli O157:H7 strain associated with an outbreak of hemorrhagic colitis.

ABSTRACT

Gnotobiotic pigs inoculated with an Escherichia coli O157:H7 strain isolated from a human with hemorrhagic colitis developed anorexia, lethargy, and watery diarrhea. Bacteria diffusely colonized the cecum and colon surfaces and the crypt epithelium. At bacterial attachment sites, microvilli were effaced, and epithelial cells were irregularly shaped, rounded, or detached. Submucosa, lamina propria, and mesentery were markedly edematous and contained many inflammatory cells.

This article has been cited by other articles:

• Baker, D. R., Moxley, R. A., Steele, M. B., LeJeune, J. T., Christopher-Hennings, J., Chen, D.-G., Hardwidge, P. R., Francis, D. H. (2007). Differences in Virulence among Escherichia coli O157:H7 Strains Isolated from Humans during Disease Outbreaks and from Healthy Cattle. Appl. Environ. Microbiol. 73: 7338-7346 [Abstract] [Full Text]  
• Sheoran, A. S., Chapman-Bonofiglio, S., Harvey, B. R., Mukherjee, J., Georgiou, G., Donohue-Rolfe, A., Tzipori, S. (2005). Human Antibody against Shiga Toxin 2 Administered to Piglets after the Onset of Diarrhea Due to Escherichia coli O157:H7 Prevents Fatal Systemic Complications. Infect. Immun. 73: 4607-4613 [Abstract] [Full Text]  
• Green, B. T., Lyte, M., Chen, C., Xie, Y., Casey, M. A., Kulkarni-Narla, A., Vulchanova, L., Brown, D. R. (2004). Adrenergic modulation of Escherichia coli O157:H7 adherence to the colonic mucosa. Am. J. Physiol. Gastrointest. Liver Physiol. 287: G1238-G1246 [Abstract] [Full Text]  
• Tzipori, S., Sheoran, A., Akiyoshi, D., Donohue-Rolfe, A., Trachtman, H. (2004). Antibody Therapy in the Management of Shiga Toxin-Induced Hemolytic Uremic Syndrome. Clin. Microbiol. Rev. 17: 926-941 [Abstract] [Full Text]  
• Batisson, I., Guimond, M.-P., Girard, F., An, H., Zhu, C., Oswald, E., Fairbrother, J. M., Jacques, M., Harel, J. (2003). Characterization of the Novel Factor Paa Involved in the Early Steps of the Adhesion Mechanism of Attaching and Effacing Escherichia coli. Infect. Immun. 71: 4516-4525 [Abstract] [Full Text]  
• Butler, J. E., Weber, P., Sinkora, M., Baker, D., Schoenherr, A., Mayer, B., Francis, D. (2002). Antibody Repertoire Development in Fetal and Neonatal Piglets. VIII. Colonization Is Required for Newborn Piglets to Make Serum Antibodies to T-Dependent and Type 2 T-Independent Antigens. J. Immunol. 169: 6822-6830 [Abstract] [Full Text]  
• WALES, A. D., CLIFTON-HADLEY, F. A., COOKSON, A. L., DIBB-FULLER, M. P., LARAGIONE, R. M., PEARSON, G. R., WOODWARD, M. J. (2002). Production of attaching-effacing lesions in ligated large intestine loops of 6-month-old sheep by Escherichia coli O157:H7. J Med Microbiol 51: 755-763 [Abstract] [Full Text]  
• Abe, H., Tatsuno, I., Tobe, T., Okutani, A., Sasakawa, C. (2002). Bicarbonate Ion Stimulates the Expression of Locus of Enterocyte Effacement-Encoded Genes in Enterohemorrhagic Escherichia coli O157:H7. Infect. Immun. 70: 3500-3509 [Abstract] [Full Text]  
• TAGUCHI, H., TAKAHASHI, M., YAMAGUCHI, H., OSAKI, T., KOMATSU, A., FUJIOKA, Y., KAMIYA, S. (2002). Experimental infection of germ-free mice with hyper-toxigenic enterohaemorrhagic Escherichia coli O157:H7, strain 6. J Med Microbiol 51: 336-343 [Abstract] [Full Text]  
• Mukherjee, J., Chios, K., Fishwild, D., Hudson, D., O'Donnell, S., Rich, S. M., Donohue-Rolfe, A., Tzipori, S. (2002). Human Stx2-Specific Monoclonal Antibodies Prevent Systemic Complications of Escherichia coli O157:H7 Infection. Infect. Immun. 70: 612-619 [Abstract] [Full Text]  
• Yoshimura, K., Tanimoto, A., Abe, T., Ogawa, M., Yutsudo, T., Kashimura, M., Yoshida, S.-i. (2002). Shiga Toxin 1 and 2 Induce Apoptosis in the Amniotic Cell Line WISH. Reproductive Sciences 9: 22-26 [Abstract]  
• Andrutis, K. A., Riggle, P. J., Kumamoto, C. A., Tzipori, S. (2000). Intestinal Lesions Associated with Disseminated Candidiasis in an Experimental Animal Model. J. Clin. Microbiol. 38: 2317-2323 [Abstract] [Full Text]  
• Klapproth, J.-M. A., Scaletsky, I. C. A., McNamara, B. P., Lai, L.-C., Malstrom, C., James, S. P., Donnenberg, M. S. (2000). A Large Toxin from Pathogenic Escherichia coli Strains That Inhibits Lymphocyte Activation. Infect. Immun. 68: 2148-2155 [Abstract] [Full Text]  
• Dean-Nystrom, E. A., Pohlenz, J. F. L., Moon, H. W., O'Brien, A. D. (2000). Escherichia coli O157:H7 Causes More-Severe Systemic Disease in Suckling Piglets than in Colostrum-Deprived Neonatal Piglets. Infect. Immun. 68: 2356-2358 [Abstract] [Full Text]  
• Price, S. B., Cheng, C.-M., Kaspar, C. W., Wright, J. C., DeGraves, F. J., Penfound, T. A., Castanie-Cornet, M.-P., Foster, J. W. (2000). Role of rpoS in Acid Resistance and Fecal Shedding of Escherichia coli O157:H7. Appl. Environ. Microbiol. 66: 632-637 [Abstract] [Full Text]  
• Abe, A., Heczko, U., Hegele, R. G., Brett Finlay, B. (1998). Two Enteropathogenic Escherichia coli Type III Secreted Proteins, EspA and EspB, Are Virulence Factors. J. Exp. Med. 188: 1907-1916 [Abstract] [Full Text]  
• Francis, D. H., Grange, P. A., Zeman, D. H., Baker, D. R., Sun, R., Erickson, A. K. (1998). Expression of Mucin-Type Glycoprotein K88 Receptors Strongly Correlates with Piglet Susceptibility to K88+ Enterotoxigenic Escherichia coli, but Adhesion of This Bacterium to Brush Borders Does Not. Infect. Immun. 66: 4050-4055 [Abstract] [Full Text]  
• Perna, N. T., Mayhew, G. F., Posfai, G., Elliott, S., Donnenberg, M. S., Kaper, J. B., Blattner, F. R. (1998). Molecular Evolution of a Pathogenicity Island from Enterohemorrhagic Escherichia coli O157:H7. Infect. Immun. 66: 3810-3817 [Abstract] [Full Text]  
• Paton, J. C., Paton, A. W. (1998). Pathogenesis and Diagnosis of Shiga Toxin-Producing Escherichia coli Infections. Clin. Microbiol. Rev. 11: 450-479 [Abstract] [Full Text]  
• Voss, E., Paton, A. W., Manning, P. A., Paton, J. C. (1998). Molecular Analysis of Shiga Toxigenic Escherichia coli O111:H- Proteins Which React with Sera from Patients with Hemolytic-Uremic Syndrome. Infect. Immun. 66: 1467-1472 [Abstract] [Full Text]  
• Karpman, D., Hakansson, A., Perez, M.-T. R., Isaksson, C., Carlemalm, E., Caprioli, A., Svanborg, C. (1998). Apoptosis of Renal Cortical Cells in the Hemolytic-Uremic Syndrome: In Vivo and In Vitro Studies. Infect. Immun. 66: 636-644 [Abstract] [Full Text]  
• Isogai, E., Isogai, H., Kimura, K., Hayashi, S., Kubota, T., Fujii, N., Takeshi, K. (1998). Role of Tumor Necrosis Factor Alpha in Gnotobiotic Mice Infected with an Escherichia coli O157:H7 Strain. Infect. Immun. 66: 197-202 [Abstract] [Full Text]