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Infect Immun. 1990 September; 58(9): 2834-2839

Survival and antigenic profile of irradiated malarial sporozoites in infected liver cells.

A Suhrbier, L A Winger, E Castellano and R E Sinden

Department of Pure and Applied Biology, Imperial College, London, United Kingdom.

ABSTRACT

Exoerythrocytic (EE) stages of Plasmodium berghei derived from irradiated sporozoites were cultured in vitro in HepG2 cells. They synthesized several antigens, predominantly but not exclusively those expressed by normal early erythrocytic schizonts. After invasion, over half the intracellular sporozoites, both normal and irradiated, appeared to die. After 24 h, in marked contrast to the normal parasites, EE parasites derived from irradiated sporozoites continued to break open, shedding their antigens into the cytoplasm of the infected host cells. Increasing radiation dosage, which has previously been shown to reduce the ability of irradiated sporozoites to protect animals, correlated with reduced de novo antigen synthesis by EE parasites derived from irradiated sporozoites.

Infect Immun. 1990 September; 58(9): 2834-2839




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