This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Gay, F. W. Articles by Baskerville, A. Search for Related Content PubMed PubMed Citation Articles by Gay, F. W. Articles by Baskerville, A.

 Previous Article  |  Next Article 

Infect Immun. 1972 July; 6(1): 83-91
Copyright © 1972 American Society for Microbiology. All Rights Reserved.

Etiology of Chronic Pneumonia in Rats and a Study of the Experimental Disease in Mice

Department of Microbiology, Queen's University of Belfast, and Ministry of Agriculture, Veterinary Research Laboratories, Stormont, Belfast, Northern Ireland

ABSTRACT

The lungs of conventional rats with chronic pneumonia contained Streptobacillus moniliformis and Mycoplasma pulmonis. These organisms singly and in combination failed to produce lung disease when inoculated into specific pathogen-free rats. On the other hand, diseased lung homogenate not containing cultivable organisms caused a chronic pneumonia when inoculated into specific pathogen-free rats. The organism involved was seen by electron microscopy and is morphologically indistinguishable from the grey lung agent of Andrewes and Glover and Nelson's enzootic bronchiectasis "virus." All of these agents have morphological and biological properties which indicate close relationship to the mycoplasmas. However, we failed to culture them either in tissue cultures or on inanimate media and conclude that a group of highly fastidious mycoplasma-like agents are a cause of chronic pneumonia in rodents.