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Infect Immun. 1972 August; 6(2): 149-155
Copyright © 1972 American Society for Microbiology. All Rights Reserved.

Effect of Vincristine Sulfate on Pseudomonas Infections in Monkeys

¹ Division of Infectious Diseases, Department of Medicine, The Ohio State University College of Medicine, Columbus, Ohio 43210

ABSTRACT

In rhesus monkeys, intravenous challenge with 0.6 x 10¹⁰ to 2.2 x 10¹⁰Pseudomonas aeruginosa organisms caused acute illness of 4 to 5 days' duration with spontaneous recovery in 13 of 15 monkeys; blood cultures became negative 3 to 17 days after challenge. Leukocytosis was observed in all monkeys. Intravenous or intratracheal inoculation of 2.0 to 2.5 mg of vincristine sulfate was followed by leukopenia in 4 to 5 days. Intravenous inoculation of 4.2 x 10¹⁰ to 7.8 x 10¹⁰ pyocin type 6 Pseudomonas organisms in monkeys given vincristine sulfate 4 days previously resulted in fatal infection in 11 of 14 monkeys, whereas none of four receiving Pseudomonas alone died. These studies suggest that an antimetabolite-induced leukopenia predisposes to severe Pseudomonas sepsis and that such monkeys may serve as a biological model for study of comparative efficacy of antimicrobial agents.