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Infect Immun. 1972 September; 6(3): 302-307
Copyright © 1972 American Society for Microbiology. All Rights Reserved.

Nicotinamide Adenine Dinucleotide Glycohydrolase Activity in Guinea Pig Polymorphonuclear Leukocytes

¹ Departments of Biochemistry and Medicine, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina 27103

ABSTRACT

An enzyme is present in extracts of guinea pig polymorphonuclear leukocytes which can catalyze the hydrolysis of pyridine nucleotides. The enzyme is equally active toward nicotinamide adenine dinucleotide (NAD) or NAD phosphate, has an acid pH optimum, and is inhibited by either nicotinamide or isonicotinic acid hydrazide. This enzyme might be involved in the regulation of the pyridine nucleotide concentration within the leukocyte.