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Infect Immun. 1972 September; 6(3): 339-343
Copyright © 1972 American Society for Microbiology. All Rights Reserved.

Transplacental Transmission of Venezuelan Equine Encephalomyelitis Virus in Mice

^a U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland 21701

ABSTRACT

Transplacental infection of mouse fetuses with Venezuelan equine encephalomyelitis was produced by intraperitoneal injection of dams at various stages of gestation with 10³ suckling mouse intracerebral median lethal doses of an attenuated strain (TC-83). Virus inoculation, at times ranging from 6 days prior to mating to 9 days after conception, had no effect on conception rate, litter size, or survival of the newborn. Inoculation of the dam from the 10th to 13th days of gestation resulted in decreased litter size, an increase in stillbirths, and a decrease in birth-to-weaning survival. Inoculation of the dams later in gestation only decreased the birth-to-weaning survival. No evidence of morphologic abnormality was noted in any of the newborn.

¹ Present address: Rutherford Animal Hospital, 924 South Haskell, Dallas, Texas 75223.