This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Delor, I Articles by Cornelis, G R Search for Related Content PubMed PubMed Citation Articles by Delor, I Articles by Cornelis, G R

 Previous Article  |  Next Article 

Infect Immun. 1992 October; 60(10): 4269-4277

Role of Yersinia enterocolitica Yst toxin in experimental infection of young rabbits.

Microbial Pathogenesis Unit, International Institute of Cellular and Molecular Pathology, Brussels, Belgium.

ABSTRACT

We constructed a Yst-negative mutant of Yersinia enterocolitica W1024 by reverse genetics, and we compared the virulence of the yst+ and yst isogenic strains in an experimental oral infection of the young rabbit. The rabbits infected with the yst+ strain suffered from the diarrhea and lost weight, and most of them died. By contrast, the occurrence of diarrhea, weight loss, and death in the group of rabbits infected with the yst mutant was as low as that in the group of uninfected rabbits. Bacteria from both strains were excreted in the feces and induced a serum antibody response against Yop proteins. The yst mutant disappeared more rapidly from the feces. We conclude that the enterotoxin Yst is a major factor involved in the Y. enterocolitica-associated diarrhea in the young rabbit. Given the similarity with the symptoms observed for children, this result suggests that Yst could also be an important factor in diarrhea in young children infected with Y. enterocolitica.

This article has been cited by other articles:

• Axler-DiPerte, G. L., Miller, V. L., Darwin, A. J. (2006). YtxR, a Conserved LysR-Like Regulator That Induces Expression of Genes Encoding a Putative ADP-Ribosyltransferase Toxin Homologue in Yersinia enterocolitica. J. Bacteriol. 188: 8033-8043 [Abstract] [Full Text]  
• Zhang, W., Berberov, E. M., Freeling, J., He, D., Moxley, R. A., Francis, D. H. (2006). Significance of heat-stable and heat-labile enterotoxins in porcine colibacillosis in an additive model for pathogenicity studies.. Infect. Immun. 74: 3107-3114 [Abstract] [Full Text]  
• Singh, I., Virdi, J. S (2004). Production of Yersinia stable toxin (YST) and distribution of yst genes in biotype 1A strains of Yersinia enterocolitica. J Med Microbiol 53: 1065-1068 [Abstract] [Full Text]  
• Di Biase, A. M., Tinari, A., Pietrantoni, A., Antonini, G., Valenti, P., Conte, M. P., Superti, F. (2004). Effect of bovine lactoferricin on enteropathogenic Yersinia adhesion and invasion in HEp-2 cells. J Med Microbiol 53: 407-412 [Abstract] [Full Text]  
• Kampik, D., Schulte, R., Autenrieth, I. B. (2000). Yersinia enterocolitica Invasin Protein Triggers Differential Production of Interleukin-1, Interleukin-8, Monocyte Chemoattractant Protein 1, Granulocyte-Macrophage Colony-Stimulating Factor, and Tumor Necrosis Factor Alpha in Epithelial Cells: Implications for Understanding the Early Cytokine Network in Yersinia Infections. Infect. Immun. 68: 2484-2492 [Abstract] [Full Text]  
• Schmiel, D. H., Young, G. M., Miller, V. L. (2000). The Yersinia enterocolitica Phospholipase Gene yplA Is Part of the Flagellar Regulon. J. Bacteriol. 182: 2314-2320 [Abstract] [Full Text]  
• Grant, T., Bennett-Wood, V., Robins-Browne, R. M. (1998). Identification of Virulence-Associated Characteristics in Clinical Isolates of Yersinia enterocolitica Lacking Classical Virulence Markers. Infect. Immun. 66: 1113-1120 [Abstract] [Full Text]