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Clonal relationships among Escherichia coli strains that cause hemorrhagic colitis and infantile diarrhea.

Department of Biology, Pennsylvania State University, University Park 16802.

ABSTRACT

The genetic relationships among 1,300 isolates of Escherichia coli representing 16 serotypes associated with enteric disease, including O157:H7 strains recovered from patients with hemorrhagic colitis and hemolytic uremic syndrome and O26:H11, O55:H6, O55:H7, O111:H2, and O128:H2 strains, many of which were isolated originally from infants with diarrhea, were estimated from allelic variation among 20 enzyme-encoding genes detected by multilocus enzyme electrophoresis. Multiple electrophoretic types were observed among isolates of each serotype, with isolates of the same O serogroup differing on average at 28% of the enzyme loci. Comparisons of the multilocus enzyme profiles revealed that 72% of the isolates belong to 15 major electrophoretic types, each of which corresponds to a bacterial clone with a wide geographic distribution. Genetically, the O157:H7 clone is most closely related to a clone of O55:H7 strains that has long been associated with worldwide outbreaks of infantile diarrhea. We propose that the new pathogen emerged when an O55:H7-like progenitor, already possessing a mechanism for adherence to intestinal cells, acquired secondary virulence factors (Shiga-like cytotoxins and plasmid-encoded adhesins) via horizontal transfer and recombination.

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• Girardeau, J. P., Dalmasso, A., Bertin, Y., Ducrot, C., Bord, S., Livrelli, V., Vernozy-Rozand, C., Martin, C. (2005). Association of Virulence Genotype with Phylogenetic Background in Comparison to Different Seropathotypes of Shiga Toxin-Producing Escherichia coli Isolates. J. Clin. Microbiol. 43: 6098-6107 [Abstract] [Full Text]  
• DebRoy, C., Fratamico, P. M., Roberts, E., Davis, M. A., Liu, Y. (2005). Development of PCR Assays Targeting Genes in O-Antigen Gene Clusters for Detection and Identification of Escherichia coli O45 and O55 Serogroups. Appl. Environ. Microbiol. 71: 4919-4924 [Abstract] [Full Text]  
• Torres, A. G., Vazquez-Juarez, R. C., Tutt, C. B., Garcia-Gallegos, J. G. (2005). Pathoadaptive Mutation That Mediates Adherence of Shiga Toxin-Producing Escherichia coli O111. Infect. Immun. 73: 4766-4776 [Abstract] [Full Text]  
• Shen, S., Mascarenhas, M., Morgan, R., Rahn, K., Karmali, M. A. (2005). Identification of Four Fimbria-Encoding Genomic Islands That Are Highly Specific for Verocytotoxin-Producing Escherichia coli Serotype O157 Strains. J. Clin. Microbiol. 43: 3840-3850 [Abstract] [Full Text]  
• Wick, L. M., Qi, W., Lacher, D. W., Whittam, T. S. (2005). Evolution of Genomic Content in the Stepwise Emergence of Escherichia coli O157:H7. J. Bacteriol. 187: 1783-1791 [Abstract] [Full Text]  
• Friedrich, A. W., Kock, R., Bielaszewska, M., Zhang, W., Karch, H., Mathys, W. (2005). Distribution of the Urease Gene Cluster among and Urease Activities of Enterohemorrhagic Escherichia coli O157 Isolates from Humans. J. Clin. Microbiol. 43: 546-550 [Abstract] [Full Text]  
• Torres, A. G., Zhou, X., Kaper, J. B. (2005). Adherence of Diarrheagenic Escherichia coli Strains to Epithelial Cells. Infect. Immun. 73: 18-29 [Full Text]  
• Bidet, P., Mariani-Kurkdjian, P., Grimont, F., Brahimi, N., Courroux, C., Grimont, P., Bingen, E. (2005). Characterization of Escherichia coli O157 : H7 isolates causing haemolytic uraemic syndrome in France. J Med Microbiol 54: 71-75 [Abstract] [Full Text]  
• Yang, Z., Kovar, J., Kim, J., Nietfeldt, J., Smith, D. R., Moxley, R. A., Olson, M. E., Fey, P. D., Benson, A. K. (2004). Identification of Common Subpopulations of Non-Sorbitol-Fermenting, {beta}-Glucuronidase-Negative Escherichia coli O157:H7 from Bovine Production Environments and Human Clinical Samples. Appl. Environ. Microbiol. 70: 6846-6854 [Abstract] [Full Text]  
• Friedrich, A. W., Nierhoff, K. V., Bielaszewska, M., Mellmann, A., Karch, H. (2004). Phylogeny, Clinical Associations, and Diagnostic Utility of the Pilin Subunit Gene (sfpA) of Sorbitol-Fermenting, Enterohemorrhagic Escherichia coli O157:H-. J. Clin. Microbiol. 42: 4697-4701 [Abstract] [Full Text]  
• Feng, L., Wang, W., Tao, J., Guo, H., Krause, G., Beutin, L., Wang, L. (2004). Identification of Escherichia coli O114 O-Antigen Gene Cluster and Development of an O114 Serogroup-Specific PCR Assay. J. Clin. Microbiol. 42: 3799-3804 [Abstract] [Full Text]  
• Escobar-Paramo, P., Clermont, O., Blanc-Potard, A.-B., Bui, H., Le Bouguenec, C., Denamur, E. (2004). A Specific Genetic Background Is Required for Acquisition and Expression of Virulence Factors in Escherichia coli. Mol Biol Evol 21: 1085-1094 [Abstract] [Full Text]  
• Diamant, E., Palti, Y., Gur-Arie, R., Cohen, H., Hallerman, E. M., Kashi, Y. (2004). Phylogeny and Strain Typing of Escherichia coli, Inferred from Variation at Mononucleotide Repeat Loci. Appl. Environ. Microbiol. 70: 2464-2473 [Abstract] [Full Text]  
• Bertin, Y., Boukhors, K., Livrelli, V., Martin, C. (2004). Localization of the Insertion Site and Pathotype Determination of the Locus of Enterocyte Effacement of Shiga Toxin-Producing Escherichia coli Strains. Appl. Environ. Microbiol. 70: 61-68 [Abstract] [Full Text]  
• Ramachandran, V., Brett, K., Hornitzky, M. A., Dowton, M., Bettelheim, K. A., Walker, M. J., Djordjevic, S. P. (2003). Distribution of Intimin Subtypes among Escherichia coli Isolates from Ruminant and Human Sources. J. Clin. Microbiol. 41: 5022-5032 [Abstract] [Full Text]  
• Anjum, M. F., Lucchini, S., Thompson, A., Hinton, J. C. D., Woodward, M. J. (2003). Comparative Genomic Indexing Reveals the Phylogenomics of Escherichia coli Pathogens. Infect. Immun. 71: 4674-4683 [Abstract] [Full Text]  
• Liebana, E., Smith, R. P., Lindsay, E., McLaren, I., Cassar, C., Clifton-Hadley, F. A., Paiba, G. A. (2003). Genetic Diversity among Escherichia coli O157:H7 Isolates from Bovines Living on Farms in England and Wales. J. Clin. Microbiol. 41: 3857-3860 [Abstract] [Full Text]  
• Shaikh, N., Tarr, P. I. (2003). Escherichia coli O157:H7 Shiga Toxin-Encoding Bacteriophages: Integrations, Excisions, Truncations, and Evolutionary Implications. J. Bacteriol. 185: 3596-3605 [Abstract] [Full Text]  
• Li, B., Tsui, H.-C. T., LeClerc, J. E., Dey, M., Winkler, M. E., Cebula, T. A. (2003). Molecular analysis of mutS expression and mutation in natural isolates of pathogenic Escherichia coli. Microbiology 149: 1323-1331 [Abstract] [Full Text]  
• Neves, B. C., Shaw, R. K., Frankel, G., Knutton, S. (2003). Polymorphisms within EspA Filaments of Enteropathogenic and Enterohemorrhagic Escherichia coli. Infect. Immun. 71: 2262-2265 [Abstract] [Full Text]  
• Ratiner, Y. A., Salmenlinna, S., Eklund, M., Keskimaki, M., Siitonen, A. (2003). Serology and Genetics of the Flagellar Antigen of Escherichia coli O157:H7a,7c. J. Clin. Microbiol. 41: 1033-1040 [Abstract] [Full Text]  
• Maidhof, H., Guerra, B., Abbas, S., Elsheikha, H. M., Whittam, T. S., Beutin, L. (2002). A Multiresistant Clone of Shiga Toxin-Producing Escherichia coli O118:[H16] Is Spread in Cattle and Humans over Different European Countries. Appl. Environ. Microbiol. 68: 5834-5842 [Abstract] [Full Text]  
• Tarr, C. L., Large, T. M., Moeller, C. L., Lacher, D. W., Tarr, P. I., Acheson, D. W., Whittam, T. S. (2002). Molecular Characterization of a Serotype O121:H19 Clone, a Distinct Shiga Toxin-Producing Clone of Pathogenic Escherichia coli. Infect. Immun. 70: 6853-6859 [Abstract] [Full Text]  
• Zhang, L., Foxman, B., Marrs, C. (2002). Both Urinary and Rectal Escherichia coli Isolates Are Dominated by Strains of Phylogenetic Group B2. J. Clin. Microbiol. 40: 3951-3955 [Abstract] [Full Text]  
• Wang, L., Huskic, S., Cisterne, A., Rothemund, D., Reeves, P. R. (2002). The O-Antigen Gene Cluster of Escherichia coli O55:H7 and Identification of a New UDP-GlcNAc C4 Epimerase Gene. J. Bacteriol. 184: 2620-2625 [Abstract] [Full Text]  
• Pradel, N., Leroy-Setrin, S., Joly, B., Livrelli, V. (2002). Genomic Subtraction To Identify and Characterize Sequences of Shiga Toxin-Producing Escherichia coli O91:H21. Appl. Environ. Microbiol. 68: 2316-2325 [Abstract] [Full Text]  
• Fitzhenry, R J, Pickard, D J, Hartland, E L, Reece, S, Dougan, G, Phillips, A D, Frankel, G (2002). Intimin type influences the site of human intestinal mucosal colonisation by enterohaemorrhagic Escherichia coli O157:H7. Gut 50: 180-185 [Abstract] [Full Text]  
• Tarr, C. L., Whittam, T. S. (2002). Molecular Evolution of the Intimin Gene in O111 Clones of Pathogenic Escherichia coli. J. Bacteriol. 184: 479-487 [Abstract] [Full Text]  
• Kim, J., Nietfeldt, J., Ju, J., Wise, J., Fegan, N., Desmarchelier, P., Benson, A. K. (2001). Ancestral Divergence, Genome Diversification, and Phylogeographic Variation in Subpopulations of Sorbitol-Negative, beta -Glucuronidase-Negative Enterohemorrhagic Escherichia coli O157. J. Bacteriol. 183: 6885-6897 [Abstract] [Full Text]  
• Pacheco, A. B. F., Ferreira, L. C. S., Pichel, M. G., Almeida, D. F., Binsztein, N., Viboud, G. I. (2001). Beyond Serotypes and Virulence-Associated Factors: Detection of Genetic Diversity among O153:H45 CFA/I Heat-Stable Enterotoxigenic Escherichia coli Strains. J. Clin. Microbiol. 39: 4500-4505 [Abstract] [Full Text]  
• Barkocy-Gallagher, G. A., Arthur, T. M., Siragusa, G. R., Keen, J. E., Elder, R. O., Laegreid, W. W., Koohmaraie, M. (2001). Genotypic Analyses of Escherichia coli O157:H7 and O157 Nonmotile Isolates Recovered from Beef Cattle and Carcasses at Processing Plants in the Midwestern States of the United States. Appl. Environ. Microbiol. 67: 3810-3818 [Abstract] [Full Text]  
• Okeke, I. N., Borneman, J. A., Shin, S., Mellies, J. L., Quinn, L. E., Kaper, J. B. (2001). Comparative Sequence Analysis of the Plasmid-Encoded Regulator of Enteropathogenic Escherichia coli Strains. Infect. Immun. 69: 5553-5564 [Abstract] [Full Text]  
• Iida, K.-I., Mizunoe, Y., Wai, S. N., Yoshida, S.-I. (2001). Type 1 Fimbriation and Its Phase Switching in Diarrheagenic Escherichia coli Strains. CVI 8: 489-495 [Abstract] [Full Text]  
• Brown, E. W., LeClerc, J. E., Li, B., Payne, W. L., Cebula, T. A. (2001). Phylogenetic Evidence for Horizontal Transfer of mutS Alleles among Naturally Occurring Escherichia coli Strains. J. Bacteriol. 183: 1631-1644 [Abstract] [Full Text]  
• Coimbra, R. S., Lefevre, M., Grimont, F., Grimont, P. A. D. (2001). Clonal Relationships among Shigella Serotypes Suggested by Cryptic Flagellin Gene Polymorphism. J. Clin. Microbiol. 39: 670-674 [Abstract] [Full Text]  
• Mellies, J. L., Navarro-Garcia, F., Okeke, I., Frederickson, J., Nataro, J. P., Kaper, J. B. (2001). espC Pathogenicity Island of Enteropathogenic Escherichia coli Encodes an Enterotoxin. Infect. Immun. 69: 315-324 [Abstract] [Full Text]  
• Blank, T. E., Zhong, H., Bell, A. L., Whittam, T. S., Donnenberg, M. S. (2000). Molecular Variation among Type IV Pilin (bfpA) Genes from Diverse Enteropathogenic Escherichia coli Strains. Infect. Immun. 68: 7028-7038 [Abstract] [Full Text]  
• Tarr, P. I., Schoening, L. M., Yea, Y.-L., Ward, T. R., Jelacic, S., Whittam, T. S. (2000). Acquisition of the rfb-gnd Cluster in Evolution of Escherichia coli O55 and O157. J. Bacteriol. 182: 6183-6191 [Abstract] [Full Text]  
• Herbelin, C. J., Chirillo, S. C., Melnick, K. A., Whittam, T. S. (2000). Gene Conservation and Loss in the mutS-rpoS Genomic Region of Pathogenic Escherichia coli. J. Bacteriol. 182: 5381-5390 [Abstract] [Full Text]  
• Zhang, W.-L., Bielaszewska, M., Bockemühl, J., Schmidt, H., Scheutz, F., Karch, H. (2000). Molecular Analysis of H Antigens Reveals that Human Diarrheagenic Escherichia coli O26 Strains That Carry the eae Gene Belong to the H11 Clonal Complex. J. Clin. Microbiol. 38: 2989-2993 [Abstract] [Full Text]  
• Kimura, R., Mandrell, R. E., Galland, J. C., Hyatt, D., Riley, L. W. (2000). Restriction-Site-Specific PCR as a Rapid Test To Detect Enterohemorrhagic Escherichia coli O157:H7 Strains in Environmental Samples. Appl. Environ. Microbiol. 66: 2513-2519 [Abstract] [Full Text]  
• Zhang, W.-L., Bielaszewska, M., Liesegang, A., Tschäpe, H., Schmidt, H., Bitzan, M., Karch, H. (2000). Molecular Characteristics and Epidemiological Significance of Shiga Toxin-Producing Escherichia coli O26 Strains. J. Clin. Microbiol. 38: 2134-2140 [Abstract] [Full Text]  
• Wang, L., Rothemund, D., Curd, H., Reeves, P. R. (2000). Sequence Diversity of the Escherichia coli H7 fliC Genes: Implication for a DNA-Based Typing Scheme for E. coli O157:H7. J. Clin. Microbiol. 38: 1786-1790 [Abstract] [Full Text]  
• Sandt, C. H., Hill, C. W. (2000). Four Different Genes Responsible for Nonimmune Immunoglobulin-Binding Activities within a Single Strain of Escherichia coli. Infect. Immun. 68: 2205-2214 [Abstract] [Full Text]  
• Amor, K., Heinrichs, D. E., Frirdich, E., Ziebell, K., Johnson, R. P., Whitfield, C. (2000). Distribution of Core Oligosaccharide Types in Lipopolysaccharides from Escherichia coli. Infect. Immun. 68: 1116-1124 [Abstract] [Full Text]  
• Tarr, P. I., Bilge, S. S., Vary, J. C. Jr., Jelacic, S., Habeeb, R. L., Ward, T. R., Baylor, M. R., Besser, T. E. (2000). Iha: a Novel Escherichia coli O157:H7 Adherence-Conferring Molecule Encoded on a Recently Acquired Chromosomal Island of Conserved Structure. Infect. Immun. 68: 1400-1407 [Abstract] [Full Text]  
• ANSARUZZAMAN, M., ALBERT, M.J., NAHAR, S., BYUN, R., KATOULI, M., KUHN, I., MOLLBY, R. (2000). Clonal groups of enteropathogenic Escherichia coli isolated in case-control studies of diarrhoea in Bangladesh. J Med Microbiol 49: 177-185 [Abstract] [Full Text]  
• LeClerc, J. E., Li, B., Payne, W. L., Cebula, T. A. (1999). Promiscuous Origin of a Chimeric Sequence in the Escherichia coli O157:H7 Genome. J. Bacteriol. 181: 7614-7617 [Abstract] [Full Text]  
• Gansheroff, L. J., Wachtel, M. R., O'Brien, A. D. (1999). Decreased Adherence of Enterohemorrhagic Escherichia coli to HEp-2 Cells in the Presence of Antibodies That Recognize the C-Terminal Region of Intimin. Infect. Immun. 67: 6409-6417 [Abstract] [Full Text]  
• Kim, J., Nietfeldt, J., Benson, A. K. (1999). Octamer-based genome scanning distinguishes a unique subpopulation of Escherichia coli O157:H7 strains in cattle. Proc. Natl. Acad. Sci. USA 96: 13288-13293 [Abstract] [Full Text]  
• Gordon, D. M., FitzGibbon, F. (1999). The distribution of enteric bacteria from Australian mammals: host and geographical effects. Microbiology 145: 2663-2671 [Abstract] [Full Text]  
• Souza, V., Rocha, M., Valera, A., Eguiarte, L. E. (1999). Genetic Structure of Natural Populations of Escherichia coli in Wild Hosts on Different Continents. Appl. Environ. Microbiol. 65: 3373-3385 [Abstract] [Full Text]  
• Reid, S. D., Betting, D. J., Whittam, T. S. (1999). Molecular Detection and Identification of Intimin Alleles in Pathogenic Escherichia coli by Multiplex PCR. J. Clin. Microbiol. 37: 2719-2722 [Abstract] [Full Text]  
• Czeczulin, J. R., Whittam, T. S., Henderson, I. R., Navarro-Garcia, F., Nataro, J. P. (1999). Phylogenetic Analysis of Enteroaggregative and Diffusely Adherent Escherichia coli. Infect. Immun. 67: 2692-2699 [Abstract] [Full Text]  
• Nagy, B., Wilson, R. A., Whittam, T. S. (1999). Genetic Diversity among Escherichia coli Isolates Carrying f18 Genes from Pigs with Porcine Postweaning Diarrhea and Edema Disease. J. Clin. Microbiol. 37: 1642-1645 [Abstract] [Full Text]  
• Picard, B., Garcia, J. S., Gouriou, S., Duriez, P., Brahimi, N., Bingen, E., Elion, J., Denamur, E. (1999). The Link between Phylogeny and Virulence in Escherichia coli Extraintestinal Infection. Infect. Immun. 67: 546-553 [Abstract] [Full Text]  
• Rode, C. K., Melkerson-Watson, L. J., Johnson, A. T., Bloch, C. A. (1999). Type-Specific Contributions to Chromosome Size Differences in Escherichia coli. Infect. Immun. 67: 230-236 [Abstract] [Full Text]  
• Reid, S. D., Selander, R. K., Whittam, T. S. (1999). Sequence Diversity of Flagellin (fliC) Alleles in Pathogenic Escherichia coli. J. Bacteriol. 181: 153-160 [Abstract] [Full Text]  
• Oberst, R. D., Hays, M. P., Bohra, L. K., Phebus, R. K., Yamashiro, C. T., Paszko-Kolva, C., Flood, S. J. A., Sargeant, J. M., Gillespie, J. R. (1998). PCR-Based DNA Amplification and Presumptive Detection of Escherichia coli O157:H7 with an Internal Fluorogenic Probe and the 5' Nuclease (TaqMan) Assay. Appl. Environ. Microbiol. 64: 3389-3396 [Abstract] [Full Text]  
• Wang, L., Reeves, P. R. (1998). Organization of Escherichia coli O157 O Antigen Gene Cluster and Identification of Its Specific Genes. Infect. Immun. 66: 3545-3551 [Abstract] [Full Text]  
• Perna, N. T., Mayhew, G. F., Posfai, G., Elliott, S., Donnenberg, M. S., Kaper, J. B., Blattner, F. R. (1998). Molecular Evolution of a Pathogenicity Island from Enterohemorrhagic Escherichia coli O157:H7. Infect. Immun. 66: 3810-3817 [Abstract] [Full Text]  
• Yamaoka, Y., Kodama, T., Kashima, K., Graham, D. Y., Sepulveda, A. R. (1998). Variants of the 3' Region of the cagA Gene in Helicobacter pylori Isolates from Patients with Different H. pylori-Associated Diseases. J. Clin. Microbiol. 36: 2258-2263 [Abstract] [Full Text]  
• Feng, P., Sandlin, R. C., Park, C. H., Wilson, R. A., Nishibuchi, M. (1998). Identification of a Rough Strain of Escherichia coli O157:H7 That Produces No Detectable O157 Antigen. J. Clin. Microbiol. 36: 2339-2341 [Abstract] [Full Text]  
• Boerlin, P., Chen, S., Colbourne, J. K., Johnson, R., De Grandis, S., Gyles, C. (1998). Evolution of Enterohemorrhagic Escherichia coli Hemolysin Plasmids and the Locus for Enterocyte Effacement in Shiga Toxin-Producing E. coli. Infect. Immun. 66: 2553-2561 [Abstract] [Full Text]  
• Adu-Bobie, J., Frankel, G., Bain, C., Goncalves, A. G., Trabulsi, L. R., Douce, G., Knutton, S., Dougan, G. (1998). Detection of Intimins alpha , beta , gamma , and delta , Four Intimin Derivatives Expressed by Attaching and Effacing Microbial Pathogens. J. Clin. Microbiol. 36: 662-668 [Abstract] [Full Text]  
• Gouveia, S., Proctor, M. E., Lee, M.-S., Luchansky, J. B., Kaspar, C. W. (1998). Genomic Comparisons and Shiga Toxin Production among Escherichia coli O157:H7 Isolates from a Day Care Center Outbreak and Sporadic Cases in Southeastern Wisconsin. J. Clin. Microbiol. 36: 727-733 [Abstract] [Full Text]  
• Boyd, E. F., Hartl, D. L. (1998). Chromosomal Regions Specific to Pathogenic Isolates of Escherichia coli Have a Phylogenetically Clustered Distribution. J. Bacteriol. 180: 1159-1165 [Abstract] [Full Text]  
• Nataro, J. P., Kaper, J. B. (1998). Diarrheagenic Escherichia coli. Clin. Microbiol. Rev. 11: 142-201 [Abstract] [Full Text]  
• Strauss, E. J., Falkow, S. (1997). Microbial Pathogenesis: Genomics and Beyond. Science 276: 707-712 [Abstract] [Full Text]  
• Ojuawo, A., Louis, D. S., Lindley, K. J, Milla, P. J (1997). Non-infective colitis in infancy: evidence in favour of minor immunodeficiency in its pathogenesis. Arch. Dis. Child. 76: 345-348 [Abstract] [Full Text]  
• LeClerc, J. E., Li, B., Payne, W. L., Cebula, T. A. (1996). High Mutation Frequencies Among Escherichia coli and Salmonella Pathogens. Science 274: 1208-1211 [Abstract] [Full Text]