This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Verjans, G M
Right arrow Articles by Kusters, J G
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Verjans, G M
Right arrow Articles by Kusters, J G

 Previous Article  |  Next Article 

Infection and Immunity, June 1994, p. 2229-2235, Vol. 62, No. 6
0019-9567/1994/$04.00+0     DOI:

research-article

Entrance and survival of Salmonella typhimurium and Yersinia enterocolitica within human B- and T-cell lines.

G M Verjans, J H Ringrose, L van Alphen, T E Feltkamp, and J G Kusters

Department of Ophthalmo-Immunology, The Netherlands Ophthalmic Research Institute, Amsterdam.

ABSTRACT

Lymphocytes, located within the Peyer's patches, might be involved in the dissemination of enteropathogenic Salmonella typhimurium and Yersinia enterocolitica bacteria. To test this hypothesis, we have investigated the susceptibility of human B- and T-cell lines to bacterial adhesion and invasion. The two S. typhimurium strains analyzed were highly invasive, while the two Y. enterocolitica (O:8) strains adhered to the B- and T-cell lines but did not enter the cell lines in significant amounts. We hypothesize that the incapability of the Y. enterocolitica (O:8) strains to enter the human B- and T-cell lines is most probably due to the bacterial inability to induce the internalization process upon adhesion to both cell lines. Although immortalized B- and T-cell lines were used in this study, the results presented suggest the possibility that both cell types could play a role in the dissemination of intracellularly residing S. typhimurium in vivo.

Infection and Immunity, June 1994, p. 2229-2235, Vol. 62, No. 6
0019-9567/1994/$04.00+0     DOI:




This article has been cited by other articles:

  • Heithoff, D. M., Badie, G., Julio, S. M., Enioutina, E. Y., Daynes, R. A., Sinsheimer, R. L., Mahan, M. J. (2007). In Vivo-Selected Mutations in Methyl-Directed Mismatch Repair Suppress the Virulence Attenuation of Salmonella dam Mutant Strains following Intraperitoneal, but Not Oral, Infection of Naive Mice. J. Bacteriol. 189: 4708-4717 [Abstract] [Full Text]  
  • Rosales-Reyes, R., Alpuche-Aranda, C., Ramirez-Aguilar, M. d. l. L., Castro-Eguiluz, A. D., Ortiz-Navarrete, V. (2005). Survival of Salmonella enterica Serovar Typhimurium within Late Endosomal-Lysosomal Compartments of B Lymphocytes Is Associated with the Inability To Use the Vacuolar Alternative Major Histocompatibility Complex Class I Antigen-Processing Pathway. Infect. Immun. 73: 3937-3944 [Abstract] [Full Text]  
  • Ringrose, J. H., Meiring, H. D., Speijer, D., Feltkamp, T. E. W., van Els, C. A. C. M., de Jong, A. P. J. M., Dankert, J. (2004). Major Histocompatibility Complex Class I Peptide Presentation after Salmonella enterica Serovar Typhimurium Infection Assessed via Stable Isotope Tagging of the B27-Presented Peptide Repertoire. Infect. Immun. 72: 5097-5105 [Abstract] [Full Text]  
  • Janssen, R., van Wengen, A., Verhard, E., de Boer, T., Zomerdijk, T., Ottenhoff, T. H. M., van Dissel, J. T. (2002). Divergent Role for TNF-{alpha} in IFN-{gamma}-Induced Killing of Toxoplasma gondii and Salmonella typhimurium Contributes to Selective Susceptibility of Patients with Partial IFN-{gamma} Receptor 1 Deficiency. J. Immunol. 169: 3900-3907 [Abstract] [Full Text]  
  • RINGROSE, J. H., MUIJSERS, A. O., PANNEKOEK, Y., YARD, B. A., BOOG, C. J. P., ALPHEN, L. V., DANKERT, J., FELTKAMP, T. E. W. (2001). Influence of infection of cells with bacteria associated with reactive arthritis on the peptide repertoire presented by HLA-B27. J Med Microbiol 50: 385-389 [Abstract] [Full Text]  
  • Stanley, T. L., Ellermeier, C. D., Slauch, J. M. (2000). Tissue-Specific Gene Expression Identifies a Gene in the Lysogenic Phage Gifsy-1 That Affects Salmonella enterica Serovar Typhimurium Survival in Peyer's Patches. J. Bacteriol. 182: 4406-4413 [Abstract] [Full Text]  
  • Gulig, P. A., Doyle, T. J., Hughes, J. A., Matsui, H. (1998). Analysis of Host Cells Associated with the Spv-Mediated Increased Intracellular Growth Rate of Salmonella typhimurium in Mice. Infect. Immun. 66: 2471-2485 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»