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Infection and Immunity, August 1994, p. 3576-3579, Vol. 62, No. 8
0019-9567/1994/$04.00+0     DOI:

research-article

Interstrain conservation of babesial RAP-1 surface-exposed B-cell epitopes despite rap-1 genomic polymorphism.

C E Suarez, T F McElwain, I Echaide, S Torioni de Echaide, and G H Palmer

Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164-7040.

ABSTRACT

Members of the babesial rhoptry-associated protein 1 (RAP-1) family express surface-exposed B-cell epitopes and are candidate antigens for vaccine development. The relationship between rap-1 genomic polymorphism and surface-exposed B-cell epitope expression was analyzed by comparison of biological clones of Mexico strain Babesia bigemina and Babesia bovis with strains isolated in Argentina. Despite genomic polymorphism between strains, including sequences located within the open reading frame, defined RAP-1 B-cell surface epitopes and RAP-1 molecular size were conserved in both B. bovis and B. bigemina.

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Infection and Immunity, August 1994, p. 3576-3579, Vol. 62, No. 8
0019-9567/1994/$04.00+0     DOI:

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