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Infect. Immun., Jul 1995, 2790-2792, Vol 63, No. 7
Copyright © 1995, American Society for Microbiology

Role of interleukin-6 in T-cell activation during primary and secondary infection with Listeria monocytogenes

Z Liu, RJ Simpson and C Cheers
Department of Microbiology, University of Melbourne, Parkville, Victoria, Australia.

Injection of recombinant interleukin-6 (IL-6) into mice enhances recovery from infection with Listeria monocytogenes. In this study, the role of IL-6 during primary and secondary Listeria infection was further tested. Neutralization of IL-6 by polyclonal antibody exacerbated primary infection and significantly delayed gamma interferon production by cultured spleen cells. In contrast, administration of anti-IL-6 antibody at the time of secondary infection did not affect the recovery of mice from infection or gamma interferon production, showing that activated T cells are not dependent on IL-6.

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