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Infect. Immun., Apr 1996, 1126-1132, Vol 64, No. 4
Copyright © 1996, American Society for Microbiology

Transfer of a CD4+ Th1 cell line to nude mice effects clearance of Rhodococcus equi from the lung

ST Kanaly, SA Hines and GH Palmer
Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington, USA.

Rhodococcus equi, and intracellular respiratory pathogen, causes sever e granulomatous pneumonia in humans with AIDS and in young horses. Pulmonary clearance of R. equi requires functional CD4+ T cells and gamma interferon (IFN-gamma) expression from bronchial lymph node cells. The purpose of this study was to investigate whether R. equi- specific CD4+ Th1 cells could effect clearance of R. equi from the lung. Adoptive transfer of a clearance of R. equi from the lungs. In contrast, mice transfused with a R. equi-specific CD4+ Th2 cell line expressed interleukin-4 but not IFN-gamma mRNA, failed to clear pulmonary infection, and developed granulomas in the lung. Control mice, which did not receive cells, did not produce IFN-gamma or interleukin-4 and developed small pulmonary granulomas. These results clearly show that a Th1 response is sufficient to effect pulmonary clearance of R. equi.

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