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Infect. Immun., Oct 1997, 4330-4333, Vol 65, No. 10
Copyright © 1997, American Society for Microbiology

Interaction between Entamoeba histolytica and intestinal epithelial cells involves a CD44 cross-reactive protein expressed on the parasite surface

P Renesto, PJ Sansonetti and N Guillen
Unite de Pathogenie Microbienne Moleculaire, Institut National de la Sante et de la Recherche Medicale U389, Institut Pasteur, Paris, France. prenesto@pasteur.fr

This study shows that Entamoeba histolytica binds hyaluronic acid. The binding molecule was identified as an 80-kDa membrane protein and was recognized by anti-CD44 monoclonal antibodies. These data indicate that a CD44 cross-reacting adherence molecule is expressed on E. histolytica.

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