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Infect. Immun., Feb 1997, 794-797, Vol 65, No. 2
Copyright © 1997, American Society for Microbiology

Identification of a frameshift mutation resulting in premature termination and loss of cell wall anchoring of the PAc antigen of Streptococcus mutans GS-5

Y Murakami, Y Nakano, Y Yamashita and T Koga
Department of Preventive Dentistry, Kyushu University Faculty of Dentistry, Fukuoka, Japan.

Most strains of Streptococcus mutans possess a 190-kDa protein antigen (PAc) on their cell surfaces, while strain GS-5 produces extracellularly a 155-kDa PAc protein. The pac gene of strain GS-5 consists of 3,477 bp and codes for a protein of 1,158 amino acids. One insertion of an adenine into the 3,469th, 3,470th, or 3,471st position from the start codon results in a frameshift mutation at codon 1157 with subsequent termination after 3 additional codons.

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