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Infect. Immun., 02 1997, 822-828, Vol 65, No. 2
Copyright © 1997, American Society for Microbiology

Characterization of the diversity and the transferrin-binding domain of gonococcal transferrin-binding protein 2

CN Cornelissen, JE Anderson and PF Sparling
Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill 27599, USA. cornelis@med.unc.edu

The molecular weight heterogeneities of Tbp1 and Tbp2 among a panel of 45 gonococcal isolates were assessed. The tbpB genes from four of these strains were sequenced to characterize the Tbp2 sequence diversity among gonococci. By expressing truncated versions of gonococcal Tbp2, we delimited the extent of Tbp2 necessary for transferrin binding in a Western blot.

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